Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | MAPK14 | Q16539 | 13/20 | 0.62 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.54 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5106114 | 0.84 | MAPK14 (0.57) | MAPK14RIPK2HSPB1CYP2C9MAPK11 | |
| SCHEMBL5098258 | 0.82 | MAPK14 (0.66) | MAPK14RIPK2HSPB1CYP2C9MAPK11 | |
| SCHEMBL5110807 | 0.80 | MAPK14 (0.66) | MAPK14RIPK2HSPB1CYP2C9MAPK11 | |
| SCHEMBL5630096 | 0.79 | MAPK14 (0.87) | MAPK14HSPB1CYP2C9MAPK11 | |
| SCHEMBL16576384 | 0.79 | MAPK14 (0.64) | MAPK14RIPK2HSPB1CYP2C9MAPK11 | |
| SCHEMBL4700588 | 0.78 | MAPK1 (0.58) | MAPK1POLBMAPK14HSPB1ALDH1A1 | |
| SCHEMBL1140070 | 0.77 | MAPK14 (0.54) | MAPK14MAPK11 | |
| SCHEMBL5494292 | 0.77 | LCK (0.63) | MAPK1POLBMAPK14 | |
| SCHEMBL5106052 | 0.77 | MAPK14 (1.00) | MAPK14RIPK2HSPB1CYP2C9MAPK11 | |
| SCHEMBL31367847 | 0.77 | MAPK14 (0.74) | MAPK14RIPK2HSPB1CYP2C9MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7396843-B2 | 5′-carbamoyl-1,1′-biphenyl-4-carboxamide derivatives and their use as p38 kinase inhibitors | GLAXO GROUP LIMITED (GB) | 2008-07-08 | — | — | US | disclosed |
| US-20050038014-A1 | 5'-carbamoyl-1,1' biphenyl-4-carboxamide derivatives and their use as p38 kinase inhibitors | GLAXO GROUP LIMITED (GB) | 2005-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050038014-A1 | 5'-carbamoyl-1,1' biphenyl-4-carboxamide derivatives and their use as p38 kinase inhibitors | MAPK1, MAP4K2, MAP3K1 | MAPK1 1/4885POLB 3042/4885MAPK14 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.