Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.73 |
| ▸ | FAAH | O00519 | 5/20 | 0.56 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | MIF | P14174 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23766626 | 0.92 | CYP1A2 (0.68) | CYP1A2FAAHSLC1A3LMNAPOLB | |
| SCHEMBL28226501 | 0.90 | CYP1A2 (0.66) | CYP1A2FAAHSLC1A3LMNAPOLB | |
| SCHEMBL8692101 | 0.89 | CYP1A2 (0.64) | CYP1A2FAAHSLC1A3CYP3A4RAB9A | |
| SCHEMBL20901379 | 0.86 | CYP1A2 (0.61) | CYP1A2FAAHSLC1A3POLBMEN1 | |
| SCHEMBL11060563 | 0.84 | CYP1A2 (0.58) | CYP1A2FAAHSLC1A3LMNAMEN1 | |
| SCHEMBL5658218 | 0.84 | CYP1A2 (0.59) | CYP1A2FAAHSLC1A3POLBMEN1 | |
| SCHEMBL14338246 | 0.83 | CYP1A2 (0.58) | CYP1A2FAAHSLC1A3POLBMEN1 | |
| SCHEMBL31115930 | 0.83 | CYP1A2 (0.61) | CYP1A2FAAHSLC1A3LMNAMEN1 | |
| SCHEMBL8604298 | 0.83 | CYP1A2 (0.57) | CYP1A2FAAHSLC1A3LMNAPOLB | |
| SCHEMBL9263653 | 0.83 | CYP1A2 (0.57) | CYP1A2FAAHLMNAALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7468380-B2 | Nitrogen-containing aromatic derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2008-12-23 | — | — | US | disclosed |
| US-7468380-B2 | Nitrogen-containing aromatic derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2008-12-23 | — | — | US | disclosed |
| CN-100339376-C | Nitrogen-containing aromatic ring derivatives | EISAI CO LTD (JP) | 2007-09-26 | — | — | CN | disclosed |
| US-20070004764-A1 | Nitrogen-containing aromatic derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2007-01-04 | — | — | US | disclosed |
| US-20070004764-A1 | Nitrogen-containing aromatic derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2007-01-04 | — | — | US | disclosed |
| US-7109219-B2 | Nitrogen-containing aromatic derivatives | EISAI CO., LTD. (JP) | 2006-09-19 | — | — | US | disclosed |
| US-20060004029-A1 | Nitrogen-containing aromatic derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2006-01-05 | — | — | US | disclosed |
| CN-1678607-A | Nitrogen-containing aromatic ring derivatives | EISAI CO LTD (JP) | 2005-10-05 | — | — | CN | disclosed |
| US-20050187236-A1 | Nitrogen-containing aromatic derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2005-08-25 | — | — | US | disclosed |
| EP-1522540-A1 | AZAARENE DERIVATIVES | Eisai Co., Ltd. (JP) | 2005-04-13 | — | — | EP | disclosed |
| US-4451406-A | N-Substituted imido-dicarboxylic acid diaryl ester method of preparation | BAYER AKTIENGESELLSCHAFT (DE) | 1984-05-29 | — | — | US | disclosed |
| US-4447635-A | N-Substituted imido-dicarboxylic acid diaryl ester compounds and herbicide intermediates | BAYER AKTIENGESELLSCHAFT (DE) | 1984-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060004029-A1 | Nitrogen-containing aromatic derivatives | NR0B2, NR0B1, NR4A1 | CYP1A2 81/4885FAAH 3105/4885SLC1A3 697/4885 |
| US-20050187236-A1 | Nitrogen-containing aromatic derivatives | NR0B2, NR0B1, NR4A1 | CYP1A2 81/4885FAAH 3105/4885SLC1A3 697/4885 |
| US-20070004764-A1 | Nitrogen-containing aromatic derivatives | NR0B2, NR0B1, NR4A1 | CYP1A2 81/4885FAAH 3105/4885SLC1A3 697/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.