Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 15/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 15/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 15/20 | 0.69 |
| ▸ | TSHR | P16473 | 14/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 12/20 | 0.69 |
| ▸ | LMNA | P02545 | 9/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.69 |
| ▸ | MAPT | P10636 | 3/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 13/20 | 0.67 |
| ▸ | USP2 | O75604 | 8/20 | 0.67 |
| ▸ | MEN1 | O00255 | 8/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.63 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | BLM | P54132 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5104301 | 0.91 | CYP1A2 (0.57) | CYP1A2CYP3A4CYP2C19TSHRCYP2D6 | |
| SCHEMBL5102199 | 0.90 | CYP1A2 (0.65) | CYP1A2CYP3A4CYP2C19TSHRCYP2D6 | |
| SCHEMBL5102203 | 0.87 | CYP1A2 (0.64) | CYP1A2CYP3A4CYP2C19TSHRCYP2D6 | |
| SCHEMBL4864864 | 0.87 | CYP1A2 (0.67) | CYP1A2CYP3A4CYP2C19TSHRCYP2D6 | |
| SCHEMBL4868243 | 0.86 | CYP1A2 (0.51) | CYP1A2CYP3A4CYP2C19TSHRCYP2D6 | |
| SCHEMBL3110831 | 0.84 | CYP1A2 (0.71) | CYP1A2CYP3A4CYP2C19TSHRCYP2D6 | |
| SCHEMBL5104377 | 0.83 | CYP1A2 (0.90) | CYP1A2CYP3A4CYP2C19TSHRCYP2D6 | |
| SCHEMBL4868260 | 0.82 | APP (0.70) | CYP1A2CYP3A4CYP2C19TSHRCYP2D6 | |
| SCHEMBL4863323 | 0.82 | APP (0.71) | CYP1A2CYP3A4CYP2C19TSHRCYP2D6 | |
| SCHEMBL5103948 | 0.82 | CYP1A2 (0.54) | CYP1A2CYP3A4CYP2C19TSHRCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080207614-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DIABETES AND OBESITY | SK CHEMICALS CO., LTD. (KR) | 2008-08-28 | — | — | US | claimed |
| US-20080207614-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DIABETES AND OBESITY | SK CHEMICALS CO., LTD. (KR) | 2008-08-28 | — | — | US | disclosed |
| EP-1844023-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DIABETES AND OBESITY | SK CHEMICALS CO., LTD. (KR) | 2007-10-17 | — | — | EP | disclosed |
| WO-2006071095-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DIABETES AND OBESITY | SK CHEMICALS CO., LTD. (KR) | 2006-07-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207614-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DIABETES AND OBESITY | GPR119, GCKR, GLP1R | CYP1A2 528/4885CYP3A4 441/4885CYP2C19 466/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.