Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | AVPR1A | P37288 | 7/20 | 0.51 |
| ▸ | AVPR2 | P30518 | 6/20 | 0.51 |
| ▸ | BRD4 | O60885 | 7/20 | 0.48 |
| ▸ | BRD2 | P25440 | 1/20 | 0.47 |
| ▸ | OXTR | P30559 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4151567 | 0.92 | HTT (0.60) | HTTAVPR1AAVPR2BRD4BRD2 | |
| SCHEMBL4145691 | 0.89 | AVPR1A (0.61) | AVPR1AAVPR2OXTRALDH1A1POLB | |
| SCHEMBL7332664 | 0.84 | HTT (0.49) | HTTAVPR1AAVPR2BRD4BRD2 | |
| SCHEMBL4155169 | 0.79 | HTT (0.41) | HTTAVPR1AAVPR2BRD4BRD2 | |
| SCHEMBL4152292 | 0.78 | AVPR1A (0.65) | AVPR1AAVPR2OXTRKMT2ARAB9A | |
| SCHEMBL4150867 | 0.77 | IDH1 (0.62) | AVPR1AAVPR2 | |
| SCHEMBL4145636 | 0.76 | TSHR (0.51) | AVPR1AAVPR2BRD4ALDH1A1LMNA | |
| SCHEMBL4140577 | 0.75 | AVPR2 (0.48) | AVPR1AAVPR2ALDH1A1POLBMEN1 | |
| SCHEMBL7337085 | 0.75 | AVPR2 (0.63) | AVPR1AAVPR2OXTR | |
| SCHEMBL4144847 | 0.74 | AVPR2 (0.52) | AVPR1AAVPR2OXTRALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7465722-B2 | Biphenyl vasopressin agonists | WYETH (US) | 2008-12-16 | — | — | US | disclosed |
| US-7223752-B2 | Biphenyl vasopressin agonists | WYETH (US) | 2007-05-29 | — | — | US | disclosed |
| EP-1381370-B1 | N-BIPHENYLCARBONYL- AND N-PHENYLPYRIDYLCARBONYL SUBSTITUTED BI- AND TRICYCLIC AZEPINES AND DIAZEPINES AS VASOPRESSING AGONISTS | WYETH CORP (US) | 2007-03-07 | — | — | EP | disclosed |
| US-20060276456-A1 | Biphenyl vasopressin agonists | WYETH (US) | 2006-12-07 | — | — | US | disclosed |
| US-6903091-B2 | Biphenyl vasopressin agonists | WYETH (US) | 2005-06-07 | — | — | US | disclosed |
| US-20050075328-A1 | Biphenyl vasopressin agonists | WYETH (US) | 2005-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276456-A1 | Biphenyl vasopressin agonists | AVPR2, AVPR1B, SSTR3 | HTT 1517/4885AVPR1A 4/4885AVPR2 1/4885 |
| US-20050075328-A1 | Biphenyl vasopressin agonists | AVPR2, AVPR1B, SSTR3 | HTT 1517/4885AVPR1A 4/4885AVPR2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.