Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | FBP1 | P09467 | 1/20 | 0.38 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5114471 | 0.79 | MAPK10 (0.53) | MAPK10SMN1; SMN2KDM4EALDH1A1CYP2A6 | |
| SCHEMBL1009561 | 0.76 | CYP2A6 (0.64) | MAPK10SMN1; SMN2KDM4EALDH1A1CYP2A6 | |
| SCHEMBL28006297 | 0.74 | CYP2A6 (0.62) | MAPK10SMN1; SMN2KDM4EALDH1A1CYP2A6 | |
| SCHEMBL27905069 | 0.74 | SMN1; SMN2 (0.72) | MAPK10SMN1; SMN2KDM4EALDH1A1CYP2A6 | |
| SCHEMBL11249373 | 0.73 | ALDH1A1 (0.56) | MAPK10SMN1; SMN2KDM4EALDH1A1CYP2A6 | |
| SCHEMBL14076589 | 0.72 | SMN1; SMN2 (0.55) | MAPK10SMN1; SMN2KDM4EALDH1A1CYP2A6 | |
| SCHEMBL7834558 | 0.72 | SMN1; SMN2 (0.55) | MAPK10SMN1; SMN2KDM4EALDH1A1CYP2A6 | |
| Formaldehyde SCHEMBL28266913 | 0.71 | SMN1; SMN2 (0.58) | MAPK10SMN1; SMN2KDM4EALDH1A1CYP2A6 | |
| Hydrochloric Acid SCHEMBL8659154 | 0.70 | SMN1; SMN2 (0.53) | MAPK10SMN1; SMN2KDM4EALDH1A1CYP2A6 | |
| SCHEMBL1165268 | 0.70 | SMN1; SMN2 (0.53) | MAPK10SMN1; SMN2KDM4EALDH1A1CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080182870-A1 | PYRIDO(3,2-d)PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-07-31 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080182870-A1 | PYRIDO(3,2-d)PYRIMIDINES USEFUL FOR TREATING VIRAL INFECTIONS | PNPO, DPYD, PNP | MAPK10 3480/4885SMN1; SMN2 2183/4885KDM4E 3976/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.