Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 10/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.60 |
| ▸ | ELANE | P08246 | 1/20 | 0.59 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.56 |
| ▸ | PGR | P06401 | 3/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | GBA1 | P04062 | 1/20 | 0.51 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5069436 | 1.00 | ESR1 (0.60) | ESR1KMT2ARECQLSMN1; SMN2HIF1A | |
| SCHEMBL5069483 | 0.86 | ESR1 (0.79) | ESR1ESR2PGR | |
| SCHEMBL5069478 | 0.86 | ESR1 (0.79) | ESR1ESR2PGR | |
| SCHEMBL5069475 | 0.86 | ESR1 (0.79) | ESR1ESR2PGR | |
| SCHEMBL5124515 | 0.86 | ESR1 (0.68) | ESR1ESR2PGRPTGS2CYP19A1 | |
| SCHEMBL5124519 | 0.86 | ESR1 (0.68) | ESR1ESR2PGRPTGS2CYP19A1 | |
| SCHEMBL5124512 | 0.86 | ESR1 (0.68) | ESR1ESR2PGRPTGS2CYP19A1 | |
| SCHEMBL5069489 | 0.85 | PTGS2 (0.66) | ESR1KMT2AESR2PGRPTGS2 | |
| SCHEMBL5069485 | 0.85 | PTGS2 (0.66) | ESR1KMT2AESR2PGRPTGS2 | |
| SCHEMBL1564782 | 0.82 | KMT2A (0.68) | ESR1KMT2ARECQLSMN1; SMN2HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442833-B2 | Triphenylethylene compounds as selective estrogen receptor modulators | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-28 | — | — | US | disclosed |
| EP-1692127-A2 | TRIPHENYLETHYLENE COMPOUNDS AS SELECTIVE ESTROGEN RECEPTOR MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005033056-A2 | TRIPHENYLETHYLENE COMPOUNDS AS SELECTIVE ESTROGEN RECEPTOR MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |