Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.79 |
| ▸ | MEN1 | O00255 | 1/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.79 |
| ▸ | PTGDR2 | Q9Y5Y4 | 16/20 | 0.60 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5114459 | 0.88 | ALDH1A1 (1.00) | ALDH1A1MEN1KMT2APTGDR2PABPC1 | |
| SCHEMBL5121426 | 0.85 | ALDH1A1 (0.79) | ALDH1A1MEN1KMT2APTGDR2PABPC1 | |
| SCHEMBL5107202 | 0.82 | ALDH1A1 (0.75) | ALDH1A1MEN1KMT2APTGDR2PABPC1 | |
| SCHEMBL5111420 | 0.82 | MEN1 (0.67) | ALDH1A1MEN1KMT2APTGDR2 | |
| SCHEMBL5110177 | 0.81 | MEN1 (0.72) | ALDH1A1MEN1KMT2APTGDR2 | |
| SCHEMBL5110477 | 0.81 | MEN1 (0.72) | ALDH1A1MEN1KMT2APTGDR2PABPC1 | |
| SCHEMBL5118599 | 0.79 | PTGDR2 (0.76) | ALDH1A1MEN1KMT2APTGDR2 | |
| SCHEMBL5107828 | 0.79 | PTGDR2 (0.71) | ALDH1A1MEN1KMT2APTGDR2 | |
| SCHEMBL11887749 | 0.77 | PTGDR2 (0.75) | ALDH1A1MEN1KMT2APTGDR2 | |
| SCHEMBL5115286 | 0.76 | PTGDR2 (0.85) | MEN1KMT2APTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8273740-B2 | antiallergen; not direct way to change nature of immunological response to allergen; G-protein-coupled \"chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)\" antagonist for prostaglandin PGD2, that mediates PGD2-dependent migration of blood Th2 cells; ; asthma, rhinitis, COPD | ACTELION PHARMACEUTICALS, LTD. (CH) | 2012-09-25 | — | — | US | disclosed |
| US-20080108638-A1 | 2-Sulfanyl-Benzoimidazol-1-Yl-Acetic Acid Derivatives as Crth2 Antagonists | ACTELION PHARMACEUTICALS,LTD. (CH) | 2008-05-08 | — | — | US | disclosed |
| EP-1784182-A1 | 2-SULFANYL-BENZIMIDAZOL-1-YL-ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2007-05-16 | — | — | EP | disclosed |
| WO-2006021418-A1 | 2-SULFANYL-BENZOIMIDAZOL-1-YL-ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-03-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108638-A1 | 2-Sulfanyl-Benzoimidazol-1-Yl-Acetic Acid Derivatives as Crth2 Antagonists | HRH2, HRH1, HRH3 | ALDH1A1 470/4885MEN1 4731/4885KMT2A 3454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.