Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.62 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.58 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HPGDS | O60760 | 1/20 | 0.45 |
| ▸ | DAO | P14920 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3362511 | 0.83 | HPGD (0.56) | HPGDHSD17B1HSD17B2ALDH1A1POLB | |
| SCHEMBL12987369 | 0.83 | HPGD (0.56) | HPGDHSD17B1HSD17B2ALDH1A1POLB | |
| Bromide SCHEMBL3360705 | 0.81 | HPGD (0.55) | HPGDHSD17B1HSD17B2ALDH1A1POLB | |
| Bromide SCHEMBL3361562 | 0.81 | HPGD (0.55) | HPGDHSD17B1HSD17B2ALDH1A1POLB | |
| SCHEMBL3361353 | 0.81 | HPGD (0.54) | HPGDHSD17B1HSD17B2ALDH1A1POLB | |
| SCHEMBL5924735 | 0.77 | HPGD (1.00) | HPGDHSD17B1HSD17B2ALDH1A1POLB | |
| SCHEMBL24573253 | 0.75 | HPGD (0.67) | HPGDHSD17B1HSD17B2ALDH1A1POLB | |
| SCHEMBL18186479 | 0.75 | HSD17B1 (1.00) | HSD17B1HSD17B2 | |
| SCHEMBL3011019 | 0.74 | HPGD (0.53) | HPGDHSD17B1HSD17B2ALDH1A1POLB | |
| SCHEMBL27836102 | 0.74 | HPGD (0.56) | HPGDALDH1A1POLBRAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080004325-A1 | PTP1B inhibitors | WYETH (US) | 2008-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004325-A1 | PTP1B inhibitors | PTPA, PTPRJ, PTPRR | HPGD 3761/4885HSD17B1 1152/4885HSD17B2 1637/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.