Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 4/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.47 |
| ▸ | CHRNB1 | P11230 | 3/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.47 |
| ▸ | CHRNB3 | Q05901 | 3/20 | 0.47 |
| ▸ | FPR1 | P21462 | 1/20 | 0.41 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5111716 | 0.98 | CHRNB4 (0.45) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNB3 | |
| SCHEMBL5108060 | 0.93 | CHRNB4 (0.45) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNB3 | |
| SCHEMBL5122724 | 0.88 | CHRNB4 (0.49) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNB3 | |
| SCHEMBL5108601 | 0.87 | CYP11B1 (0.43) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNB3 | |
| SCHEMBL5115900 | 0.86 | CHRNB4 (0.42) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNB3 | |
| SCHEMBL5113006 | 0.86 | CHRNA7 (0.37) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNB3 | |
| SCHEMBL5108697 | 0.86 | CHRNB4 (0.42) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNB3 | |
| SCHEMBL5115363 | 0.85 | CYP11B1 (0.41) | MEN1GAAMAPTKMT2AALDH1A1 | |
| SCHEMBL5107938 | 0.85 | CHRNB4 (0.47) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNB3 | |
| SCHEMBL5112358 | 0.85 | CHRNB4 (0.46) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040106603-A1 | Diazabicyclic compounds useful in the treatment of CNS and other disorders | PFIZER INC | 2004-06-03 | — | — | US | claimed |
| US-7442694-B2 | Diazabicyclic compounds useful in the treatment of CNS and other disorders | PFIZER INC (US) | 2008-10-28 | — | — | US | disclosed |
| US-20040106603-A1 | Diazabicyclic compounds useful in the treatment of CNS and other disorders | PFIZER INC | 2004-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040106603-A1 | Diazabicyclic compounds useful in the treatment of CNS and other disorders | DBH, CHRNA6, DDT | CHRNB4 11/4885CHRNA3 14/4885CHRNB1 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.