Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 4/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.42 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | FPR1 | P21462 | 1/20 | 0.37 |
| ▸ | FPR2 | P25090 | 1/20 | 0.37 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5108697 | 0.91 | CHRNB4 (0.42) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNB3 | |
| Hydrochloric Acid SCHEMBL5111544 | 0.90 | CHRNB4 (0.41) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNB3 | |
| SCHEMBL5108060 | 0.89 | CHRNB4 (0.45) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNB3 | |
| SCHEMBL5108370 | 0.87 | CHRNB4 (0.56) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNB3 | |
| SCHEMBL5116458 | 0.86 | CHRNB4 (0.47) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNB3 | |
| SCHEMBL5120701 | 0.86 | CYP11B2 (0.45) | CHRNB4CHRNA3KDM1ACYP11B1CYP11B2 | |
| SCHEMBL5114054 | 0.85 | CHRNB4 (0.41) | CHRNB4CHRNA3CYP11B2LMNA | |
| SCHEMBL5111716 | 0.84 | CHRNB4 (0.45) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNB3 | |
| SCHEMBL5111557 | 0.84 | CHRNB4 (0.43) | CHRNB4CHRNA3CHRNB1CHRNB2CHRNB3 | |
| SCHEMBL6836268 | 0.84 | NR1H2 (0.43) | CHRNB4CHRNA3CHRNB2NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040106603-A1 | Diazabicyclic compounds useful in the treatment of CNS and other disorders | PFIZER INC | 2004-06-03 | — | — | US | claimed |
| US-7442694-B2 | Diazabicyclic compounds useful in the treatment of CNS and other disorders | PFIZER INC (US) | 2008-10-28 | — | — | US | disclosed |
| US-20040106603-A1 | Diazabicyclic compounds useful in the treatment of CNS and other disorders | PFIZER INC | 2004-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040106603-A1 | Diazabicyclic compounds useful in the treatment of CNS and other disorders | DBH, CHRNA6, DDT | CHRNB4 11/4885CHRNA3 14/4885CHRNB1 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.