Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | TTBK1 | Q5TCY1 | 3/20 | 0.39 |
| ▸ | TTBK2 | Q6IQ55 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NEK2 | P51955 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4763425 | 0.70 | SMN1; SMN2 (0.53) | ROCK1MAPK1USP2TSHRKMT2A | |
| SCHEMBL30495475 | 0.70 | KDM4E (0.63) | LRRK2MAPK1KMT2ASMN1; SMN2POLB | |
| SCHEMBL14287375 | 0.68 | LRRK2 (0.63) | LRRK2IKBKBCHUKROCK1TTBK1 | |
| SCHEMBL13402697 | 0.68 | TTBK1 (0.78) | TTBK1TTBK2MKNK1EGFRAURKB | |
| SCHEMBL17054445 | 0.68 | MEN1 (0.67) | ROCK1KMT2ASMN1; SMN2POLBAURKB | |
| SCHEMBL9044197 | 0.66 | DYRK1A (0.53) | — | |
| SCHEMBL14287378 | 0.66 | LRRK2 (0.69) | LRRK2IKBKBCHUKROCK1TTBK1 | |
| SCHEMBL7217546 | 0.66 | POLB (0.53) | KMT2APOLBEGFRGAA | |
| SCHEMBL14547845 | 0.65 | LRRK2 (0.58) | LRRK2IKBKBCHUKROCK1TTBK1 | |
| SCHEMBL14287388 | 0.64 | LRRK2 (0.68) | LRRK2IKBKBCHUKROCK1TTBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080004295-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2008-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004295-A1 | NOVEL COMPOUNDS | SYK, BTK, LCK | LRRK2 2483/4885IKBKB 27/4885CHUK 21/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.