Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.47 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | DDX3X | O00571 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7222282 | 0.86 | AKR1C3 (0.71) | POLBAKR1C3GAAABCG2DDX3X | |
| SCHEMBL7217136 | 0.82 | POLB (0.52) | POLBAKR1C3GAAKDRMEN1 | |
| SCHEMBL7224014 | 0.82 | POLB (0.68) | POLBAKR1C3GAAMAP2K4 | |
| SCHEMBL3767781 | 0.82 | AKR1C3 (0.73) | POLBATMAKR1C3GAADDX3X | |
| SCHEMBL29040044 | 0.80 | KDM4E (0.66) | POLBATMAKR1C3GAAABCG2 | |
| SCHEMBL7223088 | 0.78 | RIPK1 (0.52) | POLBGAAMEN1KMT2AKDM4E | |
| SCHEMBL9728941 | 0.76 | NPC1 (0.67) | POLBMEN1KMT2ANPC1RAB9A | |
| SCHEMBL3769602 | 0.75 | POLB (0.52) | POLBAKR1C3GAADDX3XMEN1 | |
| SCHEMBL7456210 | 0.73 | LMNA (0.65) | POLBMEN1KMT2ANPC1RAB9A | |
| SCHEMBL2929452 | 0.72 | AKR1C3 (0.71) | POLBAKR1C3GAADDX3XMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6525061-B1 | Combinatorial libraries for drug discovery;4-((6-bromo-4-oxo-1,4-dihydroquinazolin-2-yl)amino)b enzoic acid, | WYETH | 2003-02-25 | — | — | US | disclosed |