Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.56 |
| ▸ | TEK | Q02763 | 9/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 8/20 | 0.56 |
| ▸ | ERBB3 | P21860 | 8/20 | 0.56 |
| ▸ | ERBB4 | Q15303 | 8/20 | 0.56 |
| ▸ | FLT3 | P36888 | 4/20 | 0.51 |
| ▸ | KDR | P35968 | 6/20 | 0.50 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 3/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.47 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 5/20 | 0.47 |
| ▸ | SRC | P12931 | 5/20 | 0.47 |
| ▸ | ABL2 | P42684 | 4/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.47 |
| ▸ | LCK | P06239 | 3/20 | 0.47 |
| ▸ | LYN | P07948 | 3/20 | 0.47 |
| ▸ | RET | P07949 | 3/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.47 |
| ▸ | FLT1 | P17948 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5117055 | 0.90 | EGFR (0.55) | EGFRTEKERBB2ERBB3ERBB4 | |
| SCHEMBL5118231 | 0.89 | TEK (0.63) | EGFRTEKERBB2ERBB3ERBB4 | |
| SCHEMBL5123170 | 0.89 | EGFR (0.72) | EGFRTEKERBB2ERBB3ERBB4 | |
| SCHEMBL5113051 | 0.88 | EGFR (0.64) | EGFRTEKERBB2ERBB3ERBB4 | |
| SCHEMBL5110507 | 0.83 | EGFR (0.56) | EGFRTEKERBB2ERBB3ERBB4 | |
| SCHEMBL5123455 | 0.83 | EGFR (0.80) | EGFRTEKERBB2ERBB3ERBB4 | |
| SCHEMBL1940004 | 0.78 | EGFR (0.82) | EGFRTEKERBB2ERBB3ERBB4 | |
| SCHEMBL5108648 | 0.76 | EGFR (0.78) | EGFRTEKERBB2ERBB3ERBB4 | |
| SCHEMBL1939673 | 0.76 | EGFR (0.80) | EGFRTEKERBB2ERBB3ERBB4 | |
| SCHEMBL5113943 | 0.75 | EGFR (0.82) | EGFRTEKERBB2ERBB3ERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7435739-B2 | Substituted pyrrolopyrimidines useful in the treatment of cancer | CHEN JINSHAN | 2008-10-14 | — | — | US | claimed |
| US-20050130994-A1 | Pyrrolopyre compounds useful in treatment of cancer | PFIZER INC | 2005-06-16 | — | — | US | claimed |
| US-7435739-B2 | Substituted pyrrolopyrimidines useful in the treatment of cancer | CHEN JINSHAN | 2008-10-14 | — | — | US | disclosed |
| US-20050130994-A1 | Pyrrolopyre compounds useful in treatment of cancer | PFIZER INC | 2005-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050130994-A1 | Pyrrolopyre compounds useful in treatment of cancer | TP53, CCNT1, CCNE1 | EGFR 2127/4885TEK 2316/4885ERBB2 2484/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.