Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 7/20 | 0.48 |
| ▸ | CCR9 | P51686 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.39 |
| ▸ | EDNRB | P24530 | 1/20 | 0.39 |
| ▸ | EDNRA | P25101 | 1/20 | 0.39 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5033825 | 0.83 | IMPDH2 (0.44) | IMPDH2CCR9NPC1RAB9AIMPDH1 | |
| SCHEMBL5027352 | 0.82 | IMPDH2 (0.55) | IMPDH2CCR9NPC1RAB9AIMPDH1 | |
| SCHEMBL5030804 | 0.72 | IMPDH2 (0.55) | IMPDH2NPC1RAB9AIMPDH1ALDH1A1 | |
| SCHEMBL4465379 | 0.71 | MEN1 (0.47) | IMPDH2IMPDH1KDM4EHSD17B10MEN1 | |
| SCHEMBL5032038 | 0.70 | IMPDH2 (0.55) | IMPDH2NPC1RAB9AP2RY1ALDH1A1 | |
| SCHEMBL5032059 | 0.69 | IMPDH2 (0.66) | IMPDH2NPC1RAB9AIMPDH1P2RY1 | |
| SCHEMBL10035045 | 0.68 | IMPDH2 (0.51) | IMPDH2NPC1RAB9AIMPDH1LMNA | |
| SCHEMBL5029487 | 0.67 | IMPDH2 (0.54) | IMPDH2NPC1RAB9AIMPDH1P2RY1 | |
| SCHEMBL5033768 | 0.67 | IMPDH2 (0.54) | IMPDH2NPC1RAB9AIMPDH1P2RY1 | |
| SCHEMBL5445930 | 0.67 | IL2 (0.43) | NPC1RAB9AEDNRBEDNRAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1983971-A2 | SUBSTITUTED AROMATIC COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | Synta Pharmaceuticals Corporation (US) | 2008-10-29 | — | — | EP | claimed |
| WO-2007087441-A2 | SUBSTITUTED AROMATIC COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2007-08-02 | — | — | WO | claimed |