Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | SETD2 | Q9BYW2 | 2/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.52 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.52 |
| ▸ | KMO | O15229 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6882558 | 0.89 | AURKA (0.54) | SMN1; SMN2MAPTHTTRAB9ASETD2 | |
| SCHEMBL6424561 | 0.84 | KMO (0.63) | SMN1; SMN2MAPTHTTRAB9ASETD2 | |
| SCHEMBL12764316 | 0.82 | MAPT (0.65) | SMN1; SMN2MAPTHTTRAB9ASETD2 | |
| SCHEMBL12764351 | 0.80 | MAPT (0.62) | SMN1; SMN2MAPTHTTRAB9ASETD2 | |
| SCHEMBL2979099 | 0.80 | MAPK14 (0.65) | RAB9ASETD2MAPK14 | |
| SCHEMBL14078239 | 0.79 | MAPK14 (0.65) | MAPTRAB9ASETD2MAPK14ALDH1A1 | |
| SCHEMBL27528931 | 0.79 | NPC1 (0.74) | SMN1; SMN2MAPTRAB9ASETD2MAPK14 | |
| SCHEMBL3527294 | 0.79 | MAPK14 (0.62) | RAB9ASETD2MAPK14 | |
| SCHEMBL27453736 | 0.77 | SMN1; SMN2 (0.53) | SMN1; SMN2MAPTHTTRAB9AMAPK14 | |
| SCHEMBL3956530 | 0.77 | MAPT (0.65) | SMN1; SMN2MAPTHTTRAB9AKMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7425555-B2 | Heteroaryl substituted biphenyl derivatives as p38 kinase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2008-09-16 | — | — | US | disclosed |
| US-20060089393-A1 | Heteroaryl substituted biphenyl derivatives as p38 kinase inhibitors | GLAXOSMITHKLINE LLC | 2006-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060089393-A1 | Heteroaryl substituted biphenyl derivatives as p38 kinase inhibitors | MAPK1, MAPK7, MAP3K1 | SMN1; SMN2 2815/4885MAPT 2364/4885HTT 4611/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.