Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 6/20 | 0.57 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.57 |
| ▸ | DHODH | Q02127 | 1/20 | 0.54 |
| ▸ | ELANE | P08246 | 1/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.46 |
| ▸ | ESR1 | P03372 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5123782 | 0.85 | DHODH (0.59) | MTNR1AMTNR1BDHODHELANEESR2 | |
| SCHEMBL6786317 | 0.79 | MTNR1A (0.62) | MTNR1AMTNR1BDHODHELANEESR2 | |
| SCHEMBL6791342 | 0.78 | MTNR1A (0.55) | MTNR1AMTNR1BDHODHELANEESR2 | |
| SCHEMBL24295099 | 0.76 | DHODH (0.59) | MTNR1AMTNR1BDHODHELANEESR2 | |
| SCHEMBL29819490 | 0.76 | DHODH (0.59) | MTNR1AMTNR1BDHODHELANEESR2 | |
| SCHEMBL13865468 | 0.75 | DHODH (0.58) | MTNR1AMTNR1BDHODHELANEESR2 | |
| SCHEMBL1040237 | 0.75 | DHODH (0.62) | MTNR1AMTNR1BDHODHELANEESR2 | |
| SCHEMBL2587399 | 0.75 | DHODH (0.58) | MTNR1AMTNR1BDHODHELANEESR2 | |
| SCHEMBL8117279 | 0.75 | DHODH (0.58) | MTNR1AMTNR1BDHODHELANEESR2 | |
| SCHEMBL29390984 | 0.75 | DHODH (0.58) | MTNR1AMTNR1BDHODHELANEESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1481965-B1 | AROMATIC AMINO ACID DERIVATIVES AND MEDICINAL COMPOSITIONS | ENDO HITOSHI (JP) | 2015-07-29 | — | — | EP | disclosed |
| US-7345068-B2 | Aromatic amino acid derivatives and medicinal compositions | Endou, Hitoshi (JP) | 2008-03-18 | — | — | US | disclosed |
| US-20050119256-A1 | Aromatic amino acid derivates and medicinal compositions | HITOSHI ENDOU (JP) | 2005-06-02 | — | — | US | disclosed |
| EP-1481965-A1 | AROMATIC AMINO ACID DERIVATIVES AND MEDICINAL COMPOSITIONS | Endo, Hitoshi (JP) | 2004-12-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050119256-A1 | Aromatic amino acid derivates and medicinal compositions | SLC7A1, SLC1A5, SLC7A5 | MTNR1A 2720/4885MTNR1B 3413/4885DHODH 1652/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.