Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 4/20 | 0.57 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.51 |
| ▸ | FYN | P06241 | 3/20 | 0.51 |
| ▸ | PPARG | P37231 | 4/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 2/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | PLG | P00747 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1679150 | 0.80 | CHEK2 (0.71) | CHEK2MAP4K4FYNCHEK1SRC | |
| SCHEMBL3183242 | 0.71 | PPARG (0.49) | CHEK2PPARGF2F10PLG | |
| SCHEMBL12821908 | 0.71 | FGFR1 (0.64) | SRCEGLN1THRB | |
| SCHEMBL5115373 | 0.70 | SLC2A1 (0.59) | CHEK2FYNCHEK1 | |
| SCHEMBL3175974 | 0.70 | CHEK2 (0.52) | CHEK2PPARGF2F10PLG | |
| Hydrochloric Acid SCHEMBL5120420 | 0.70 | SLC2A1 (0.59) | CHEK2FYNCHEK1 | |
| SCHEMBL13350181 | 0.69 | CHEK2 (0.60) | CHEK2F2F10PLGPLAU | |
| SCHEMBL4620276 | 0.68 | FYN (1.00) | CHEK2MAP4K4FYNCHEK1 | |
| SCHEMBL30521818 | 0.68 | FYN (1.00) | CHEK2MAP4K4FYNCHEK1 | |
| SCHEMBL3171683 | 0.68 | VDR (0.52) | CHEK2F2F10PLGPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7329678-B2 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-12 | — | — | US | claimed |