SCHEMBL5118801

SCHEMBL5118801

Cc1cc(S(=O)(=O)CNC/C=C/C(=O)N(C)Cc2ccc(C3=NCCN3C(=O)O)cc2)c(Cl)cc1Cl

nearest known ligand 0.41

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.41
BDKRB1 P46663 5/20 0.40
TP53 P04637 1/20 0.32
CCR1 P32246 1/20 0.31
GAA P10253 1/20 0.31
SLC2A1 P11166 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5118814 1.00 LMNA (0.41) LMNABDKRB1TP53CCR1GAA
SCHEMBL5114114 0.90 BDKRB1 (0.40) BDKRB1SLC2A1
SCHEMBL5114589 0.90 BDKRB1 (0.40) LMNABDKRB1TP53SLC2A1
SCHEMBL5114104 0.90 BDKRB1 (0.40) BDKRB1SLC2A1
SCHEMBL5114598 0.90 BDKRB1 (0.40) LMNABDKRB1TP53SLC2A1
SCHEMBL5114368 0.89 BDKRB1 (0.43) LMNABDKRB1TP53SLC2A1
SCHEMBL5114360 0.89 BDKRB1 (0.43) LMNABDKRB1TP53SLC2A1
SCHEMBL5124193 0.89 BDKRB1 (0.40) LMNABDKRB1CCR1SLC2A1
SCHEMBL5124199 0.89 BDKRB1 (0.40) LMNABDKRB1CCR1SLC2A1
SCHEMBL5114204 0.88 BDKRB1 (0.40) LMNABDKRB1TP53SLC2A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7361687-B2 Arylsulphonamide derivatives and methods of preparing LABORATOIRES FOURNIER SA (FR) 2008-04-22 US disclosed
US-20060084699-A1 Novel arylsulphonamide derivatives and use thereof as therapeutic agents LABORATOIRES FOURNIER SA (FR) 2006-04-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060084699-A1 Novel arylsulphonamide derivatives and use thereof as therapeutic agents UGT1A1, UGT2B7, UGT1A6 LMNA 4632/4885BDKRB1 1217/4885TP53 2886/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.