Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 11/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5119788 | 1.00 | HTR4 (0.54) | HTR4CYP3A4TDP1ACHE | |
| Hydrochloric Acid SCHEMBL5113473 | 0.99 | HTR4 (0.53) | HTR4CYP3A4TDP1ACHE | |
| Hydrochloric Acid SCHEMBL5113477 | 0.99 | HTR4 (0.53) | HTR4CYP3A4TDP1ACHE | |
| SCHEMBL5119890 | 0.88 | HTR4 (0.52) | HTR4CYP3A4ACHE | |
| SCHEMBL5119885 | 0.88 | HTR4 (0.52) | HTR4CYP3A4ACHE | |
| SCHEMBL5119894 | 0.88 | HTR4 (0.52) | HTR4CYP3A4ACHE | |
| Hydrochloric Acid SCHEMBL5115960 | 0.87 | HTR4 (0.51) | HTR4CYP3A4TDP1ACHE | |
| Hydrochloric Acid SCHEMBL5113395 | 0.87 | HTR4 (0.51) | HTR4CYP3A4TDP1ACHE | |
| Hydrochloric Acid SCHEMBL5113388 | 0.87 | HTR4 (0.51) | HTR4CYP3A4TDP1ACHE | |
| Hydrochloric Acid SCHEMBL5115956 | 0.87 | HTR4 (0.51) | HTR4CYP3A4TDP1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8816090-B2 | Benzisoxazole derivatives | PFIZER INC. (US) | 2014-08-26 | — | — | US | disclosed |
| EP-1856114-B1 | BENZISOXAZOLE DERIVATIVES | PFIZER (US) | 2014-08-20 | — | — | EP | disclosed |
| US-20080207690-A1 | Benzisoxazole Derivatives | RAQUALIA PHARMA INC. (JP) | 2008-08-28 | — | — | US | disclosed |
| EP-1856114-A1 | BENZISOXAZOLE DERIVATIVES | Pfizer, Inc. (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006090224-A1 | BENZISOXAZOLE DERIVATIVES | PFIZER JAPAN INC. (JP) | 2006-08-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207690-A1 | Benzisoxazole Derivatives | BRS3, MRGPRX4, HTR4 | HTR4 3/4885CYP3A4 142/4885TDP1 3368/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.