Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Quercetin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 known ✓ | P30518 | 1/20 | 0.87 |
| ▸ | OPRK1 known ✓ | P41145 | 1/20 | 0.87 |
| ▸ | MEN1 | O00255 | 9/20 | 0.87 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.87 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.87 |
| ▸ | CYP1A1 | P04798 | 7/20 | 0.87 |
| ▸ | CYP1B1 | Q16678 | 7/20 | 0.87 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.87 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.87 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.87 |
| ▸ | MAPT | P10636 | 6/20 | 0.87 |
| ▸ | POLH | Q9Y253 | 6/20 | 0.87 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.87 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.87 |
| ▸ | RECQL | P46063 | 5/20 | 0.87 |
| ▸ | IPMK | Q8NFU5 | 5/20 | 0.87 |
| ▸ | IP6K2 | Q9UHH9 | 5/20 | 0.87 |
| ▸ | XDH | P47989 | 5/20 | 0.87 |
| ▸ | FTO | Q9C0B1 | 5/20 | 0.87 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.87 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quercetin SCHEMBL7186872 | 1.00 | MEN1 (0.87) | MEN1KMT2ACYP1A2CYP1A1CYP1B1 | |
| Quercetin SCHEMBL27746111 | 0.93 | MEN1 (0.94) | MEN1KMT2ACYP1A2CYP1A1CYP1B1 | |
| Quercetin SCHEMBL29353785 | 0.93 | MEN1 (1.00) | MEN1KMT2ACYP1A2CYP1A1CYP1B1 | |
| Quercetin SCHEMBL17629824 | 0.93 | MEN1 (1.00) | MEN1KMT2ACYP1A2CYP1A1CYP1B1 | |
| Quercetin SCHEMBL29723041 | 0.93 | MEN1 (1.00) | MEN1KMT2ACYP1A2CYP1A1CYP1B1 | |
| Quercetin SCHEMBL29351036 | 0.93 | MEN1 (1.00) | MEN1KMT2ACYP1A2CYP1A1CYP1B1 | |
| Quercetin SCHEMBL118425 | 0.93 | MEN1 (1.00) | MEN1KMT2ACYP1A2CYP1A1CYP1B1 | |
| Quercetin SCHEMBL19723 | 0.93 | MEN1 (1.00) | MEN1KMT2ACYP1A2CYP1A1CYP1B1 | |
| Quercetin SCHEMBL31507620 | 0.93 | MEN1 (1.00) | MEN1KMT2ACYP1A2CYP1A1CYP1B1 | |
| Quercetin SCHEMBL11298145 | 0.93 | MEN1 (0.79) | MEN1KMT2ACYP1A2CYP1A1CYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109678832-A | One pot synthesis is synthesized the method and its product and application of Quercetin ester by rutin | 郑州工业应用技术学院 | 2019-04-26 | — | — | CN | disclosed |
| CN-105481814-B | A kind of synthetic method of Isorhamnetin | 陕西嘉禾生物科技股份有限公司 | 2018-08-31 | — | — | CN | disclosed |
| CN-105481814-A | Synthetic method for isorhamnetin | SHAANXI JIAHE BIOTECHNOLOGY CO LTD | 2016-04-13 | — | — | CN | disclosed |
| US-20130158107-A1 | NOVEL FLAVONOIDS AND USES THEREOF | CHIANG, WENCHANG (TW) | 2013-06-20 | — | — | US | disclosed |
| US-7863323-B1 | Flavonols | THE UNIVERSITY OF MELBOURNE (AU) | 2011-01-04 | — | — | US | disclosed |
| WO-2002020834-A2 | METHOD FOR THE IDENTIFICATION OF GENES THAT ARE INVOLVED IN THE MODULATION OF A POPTOSIS IN CELLS | EIRX THERAPEUTICS LIMITED (IE) | 2002-03-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130158107-A1 | NOVEL FLAVONOIDS AND USES THEREOF | ICAM1, FABP1, FABP3 | AVPR2 4626/4885OPRK1 2952/4885MEN1 4590/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.