Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | FABP2 | P12104 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | PPARD | Q03181 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | PTGDR2 | Q9Y5Y4 | 7/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2986505 | 0.91 | HTT (0.58) | PPARASMN1; SMN2ALDH1A1FABP2PPARG | |
| SCHEMBL2983607 | 0.89 | HTT (0.51) | PPARASMN1; SMN2ALDH1A1FABP2PPARG | |
| SCHEMBL2987871 | 0.87 | PPARA (0.52) | PPARASMN1; SMN2ALDH1A1FABP2PPARG | |
| SCHEMBL5126359 | 0.85 | PPARA (0.47) | PPARASMN1; SMN2ALDH1A1FABP2PPARG | |
| SCHEMBL5128416 | 0.83 | SLC6A4 (0.43) | SMN1; SMN2ALDH1A1MAPTRAB9AKMT2A | |
| SCHEMBL5132543 | 0.83 | SLC6A4 (0.40) | — | |
| SCHEMBL2982220 | 0.81 | PPARA (0.62) | PPARASMN1; SMN2ALDH1A1FABP2PPARG | |
| SCHEMBL11982028 | 0.81 | NPC1 (0.41) | PPARASMN1; SMN2ALDH1A1HTTPTGDR2 | |
| SCHEMBL2986695 | 0.81 | PTGDR2 (0.54) | PPARASMN1; SMN2ALDH1A1FABP2PPARG | |
| SCHEMBL2983975 | 0.80 | MAPT (0.55) | PPARASMN1; SMN2ALDH1A1FABP2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492437-B2 | 4-substituted phenoxyphenylacetic acid derivatives | ARRAY BIOPHARMA INC. (US) | 2013-07-23 | — | — | US | disclosed |
| EP-2057115-B9 | 4-SUBSTITUTED PHENOXYPHENYLACETIC ACID DERIVATIVES | ARRAY BIOPHARMA INC (US) | 2012-12-26 | — | — | EP | disclosed |
| EP-2057115-B1 | 4-SUBSTITUTED PHENOXYPHENYLACETIC ACID DERIVATIVES | ARRAY BIOPHARMA INC (US) | 2012-10-03 | — | — | EP | disclosed |
| US-8183289-B2 | 4-substituted phenoxyphenylacetic acid derivatives | ARRAY BIOPHARMA INC. (US) | 2012-05-22 | — | — | US | disclosed |