Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 8/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.38 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5132543 | 0.90 | SLC6A4 (0.40) | SLC6A4SLC6A2SLC6A3MTNR1AMTNR1B | |
| SCHEMBL2991813 | 0.85 | SLC6A4 (0.48) | SLC6A4SLC6A2SLC6A3MTNR1AMTNR1B | |
| SCHEMBL2979962 | 0.84 | LOXL2 (0.46) | SLC6A4SLC6A2MTNR1AMTNR1BHTR2A | |
| SCHEMBL5126360 | 0.83 | PPARA (0.49) | RAB9AALDH1A1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL5128413 | 0.83 | MTNR1A (0.39) | SLC6A4SLC6A2SLC6A3MTNR1AMTNR1B | |
| SCHEMBL2991810 | 0.79 | KMT2A (0.38) | MTNR1AMTNR1BLPAR1LPAR5ALDH1A1 | |
| SCHEMBL5130741 | 0.78 | CCR2 (0.40) | MTNR1AMTNR1BLPAR1ALDH1A1HPGD | |
| SCHEMBL2984362 | 0.77 | MAPK14 (0.40) | MTNR1AMTNR1BLPAR1LPAR5RAB9A | |
| SCHEMBL2979319 | 0.77 | KMT2A (0.48) | SLC6A4SLC6A2SLC6A3MTNR1AMTNR1B | |
| SCHEMBL2650122 | 0.73 | LOXL2 (0.54) | MTNR1AMTNR1BRAB9AKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492437-B2 | 4-substituted phenoxyphenylacetic acid derivatives | ARRAY BIOPHARMA INC. (US) | 2013-07-23 | — | — | US | disclosed |
| EP-2057115-B9 | 4-SUBSTITUTED PHENOXYPHENYLACETIC ACID DERIVATIVES | ARRAY BIOPHARMA INC (US) | 2012-12-26 | — | — | EP | disclosed |
| EP-2057115-B1 | 4-SUBSTITUTED PHENOXYPHENYLACETIC ACID DERIVATIVES | ARRAY BIOPHARMA INC (US) | 2012-10-03 | — | — | EP | disclosed |
| US-8183289-B2 | 4-substituted phenoxyphenylacetic acid derivatives | ARRAY BIOPHARMA INC. (US) | 2012-05-22 | — | — | US | disclosed |