Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 6/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
| ▸ | HRH2 | P25021 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5121405 | 0.89 | SIGMAR1 (0.42) | MCHR1KDM4EALDH1A1 | |
| SCHEMBL5113972 | 0.85 | CHRM5 (0.48) | CHRM5CHRM1CHRM4CHRM3OPRM1 | |
| SCHEMBL5113973 | 0.85 | CHRM5 (0.48) | CHRM5CHRM1CHRM4CHRM3OPRM1 | |
| SCHEMBL5113968 | 0.78 | CHRM5 (0.49) | CHRM5CHRM1CHRM4CHRM3OPRM1 | |
| SCHEMBL5127863 | 0.77 | CHRM5 (0.48) | CHRM5CHRM1CHRM4CHRM3OPRM1 | |
| SCHEMBL5117197 | 0.74 | CHRM5 (0.62) | CHRM5CHRM1CHRM4CHRM3OPRM1 | |
| SCHEMBL5126700 | 0.72 | CHRM5 (0.53) | CHRM5CHRM1CHRM4CHRM3OPRM1 | |
| SCHEMBL2774716 | 0.69 | CHRM5 (0.61) | CHRM5CHRM1CHRM4CHRM3OPRM1 | |
| SCHEMBL3949670 | 0.69 | CHRM5 (0.61) | CHRM5CHRM1CHRM4CHRM3OPRM1 | |
| SCHEMBL2773429 | 0.69 | CHRM5 (0.61) | CHRM5CHRM1CHRM4CHRM3OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7465751-B2 | 1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists | RANBAXY LABORATORIES LIMITED (IN) | 2008-12-16 | — | — | US | claimed |