Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | GCK | P35557 | 16/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2668297 | 1.00 | APP (0.37) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1858327 | 0.87 | APP (0.42) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1858325 | 0.87 | APP (0.42) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1864663 | 0.84 | APP (0.41) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1107471 | 0.81 | GCK (0.39) | GCK | |
| SCHEMBL2668154 | 0.81 | GAA (0.36) | GCK | |
| SCHEMBL3387053 | 0.78 | GCK (0.39) | GCK | |
| SCHEMBL1859102 | 0.77 | KCNH2 (0.52) | GCKKCNH2 | |
| SCHEMBL2668248 | 0.77 | GCK (0.43) | GCKKCNH2 | |
| SCHEMBL2655654 | 0.77 | GCK (0.43) | GCKKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293730-A1 | Tricyclo Substituted Amides | PROSIDION LIMITED (GB) | 2008-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293730-A1 | Tricyclo Substituted Amides | GPR119, SLC5A2, SLC5A1 | APP 2705/4885PSEN1 2451/4885PSEN2 2552/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.