Sugi Predict

Sugi Predict / Compounds / SCHEMBL5126941

SCHEMBL5126941

SCHEMBL5126941

CC(c1cccc(Oc2ccc(Cl)c(Cl)c2)c1)N1CCc2ccccc2C1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ OGA O60502 1/20 0.49
▸ HRH4 Q9H3N8 1/20 0.39
▸ ALDH1A1 P00352 2/20 0.39
▸ TP53 P04637 2/20 0.39
▸ HPGD P15428 2/20 0.39
▸ LMNA P02545 1/20 0.39
▸ TSHR P16473 1/20 0.39
▸ HSD17B10 Q99714 1/20 0.39
▸ GAA P10253 1/20 0.38
▸ PRMT5 O14744 4/20 0.38
▸ WDR77 Q9BQA1 4/20 0.38
▸ GABRA1 P14867 2/20 0.37
▸ GABRG2 P18507 2/20 0.37
▸ GABRB3 P28472 2/20 0.37
▸ MEN1 O00255 1/20 0.37
▸ KMT2A Q03164 1/20 0.37
▸ KMO O15229 1/20 0.37
▸ HTR2A P28223 2/20 0.37
▸ SLC6A4 P31645 2/20 0.37
▸ KCNH2 Q12809 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5120634 0.90 OGA (0.50) OGAALDH1A1TP53HPGDLMNA
SCHEMBL5128540 0.88 OGA (0.55) OGAALDH1A1TP53HPGDLMNA
SCHEMBL5127676 0.87 KCNH2 (0.46) ALDH1A1TSHRHSD17B10SLC6A4KCNH2
SCHEMBL5128323 0.86 OGA (0.51) OGAALDH1A1TP53HPGDLMNA
SCHEMBL5132002 0.83 OGA (0.48) OGAALDH1A1TP53HPGDLMNA
SCHEMBL15131063 0.82 OGA (0.56) OGAALDH1A1TP53HPGDLMNA
SCHEMBL5128313 0.79 OGA (0.55) OGAALDH1A1HPGDLMNATSHR
SCHEMBL5121371 0.77 ACHE (0.46) ALDH1A1TSHRHSD17B10SLC6A4ACHE
SCHEMBL5131986 0.76 KDM4E (0.47) OGAALDH1A1TSHRHSD17B10SLC6A4
SCHEMBL5128317 0.76 HRH3 (0.60) OGAPRMT5WDR77HRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080161344-A1 Melanin Concentrating Hormone Receptor Ligands: Substituted Tetrahydroisoquinoline Analogues NEUROGEN CORPORATION 2008-07-03 — — US claimed
WO-2005077903-A2 MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS: SUBSTITUTED TETRAHYDROISOQUINOLINE ANALOGUES NEUROGEN CORPORATION (US) 2005-08-25 — — WO claimed
US-20080161344-A1 Melanin Concentrating Hormone Receptor Ligands: Substituted Tetrahydroisoquinoline Analogues NEUROGEN CORPORATION 2008-07-03 — — US disclosed
US-20080161344-A1 Melanin Concentrating Hormone Receptor Ligands: Substituted Tetrahydroisoquinoline Analogues NEUROGEN CORPORATION 2008-07-03 — — US disclosed
US-20080161344-A1 Melanin Concentrating Hormone Receptor Ligands: Substituted Tetrahydroisoquinoline Analogues NEUROGEN CORPORATION 2008-07-03 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080161344-A1 Melanin Concentrating Hormone Receptor Ligands: Substituted Tetrahydroisoquinoline Analogues MCHR1, MCHR2, MC1R OGA 4569/4885HRH4 90/4885ALDH1A1 2248/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.