Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 9/20 | 0.76 |
| ▸ | HSP90AB1 | P08238 | 8/20 | 0.76 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.48 |
| ▸ | MGLL | Q99685 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL487558 | 0.88 | HSP90AA1 (0.74) | HSP90AA1HSP90AB1GAAMEN1KMT2A | |
| SCHEMBL487517 | 0.86 | HSP90AA1 (1.00) | HSP90AA1HSP90AB1HSP90B1ALDH1A1 | |
| SCHEMBL5130654 | 0.85 | HSP90AA1 (0.62) | HSP90AA1HSP90AB1HSP90B1ALDH1A1 | |
| SCHEMBL487543 | 0.83 | HSP90AA1 (0.74) | HSP90AA1HSP90AB1HSP90B1 | |
| SCHEMBL12218049 | 0.82 | ALDH1A1 (0.60) | HSP90AA1HSP90AB1MAPTGAAMEN1 | |
| SCHEMBL487606 | 0.82 | HSP90AA1 (0.73) | HSP90AA1HSP90AB1HSP90B1 | |
| SCHEMBL10256108 | 0.82 | HSP90AA1 (0.85) | HSP90AA1HSP90AB1HSP90B1 | |
| SCHEMBL487545 | 0.82 | HSP90AA1 (0.85) | HSP90AA1HSP90AB1HSP90B1 | |
| SCHEMBL13236654 | 0.81 | HSP90AA1 (0.71) | HSP90AA1HSP90AB1HSP90B1ALDH1A1 | |
| SCHEMBL487912 | 0.81 | HSP90AA1 (1.00) | HSP90AA1HSP90AB1MEN1KMT2AHSP90B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080306054-A1 | Pharmaceutical Compounds | ASTEX THERAPEUTICS LIMITED (GB) | 2008-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306054-A1 | Pharmaceutical Compounds | HSP90AB1, HSP90AA1, HSP90AB2P | HSP90AA1 2/4885HSP90AB1 1/4885MAPT 82/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.