Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PRKCI | P41743 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5820926 | 0.95 | ALDH1A1 (0.44) | ALDH1A1MAPTCHRM4SMN1; SMN2POLB | |
| SCHEMBL5115505 | 0.94 | ALDH1A1 (0.42) | ALDH1A1MAPTCHRM4SMN1; SMN2GAA | |
| SCHEMBL7618190 | 0.91 | ALDH1A1 (0.47) | ALDH1A1MAPTCHRM4SMN1; SMN2POLB | |
| SCHEMBL5124136 | 0.91 | CHRM4 (0.42) | ALDH1A1MAPTCHRM4SMN1; SMN2POLB | |
| SCHEMBL5814655 | 0.88 | CHRM4 (0.40) | ALDH1A1MAPTCHRM4SMN1; SMN2POLB | |
| SCHEMBL5130870 | 0.86 | GAA (0.42) | ALDH1A1MAPTCHRM4SMN1; SMN2POLB | |
| SCHEMBL5125502 | 0.85 | CHRM4 (0.42) | ALDH1A1MAPTCHRM4SMN1; SMN2LMNA | |
| SCHEMBL5130160 | 0.85 | PRKCI (0.43) | ALDH1A1MAPTSMN1; SMN2POLBRAD52 | |
| SCHEMBL5125583 | 0.85 | ESR1 (0.42) | ALDH1A1MAPTCHRM4GAALMNA | |
| SCHEMBL5123014 | 0.85 | PRKCI (0.58) | ALDH1A1MAPTCHRM4SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080045529-A1 | Use Of Thienopyrimidines | MERCK PATENT GMBH (DE) | 2008-02-21 | — | — | US | disclosed |
| US-6110920-A | TREATMENT OF CARDIOVASCULAR DISORDERS AND IMPOTENCY | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045529-A1 | Use Of Thienopyrimidines | TIE1, DPYD, TK2 | ALDH1A1 1055/4885MAPT 2997/4885CHRM4 4573/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.