Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | USP1 | O94782 | 3/20 | 0.37 |
| ▸ | WDR48 | Q8TAF3 | 3/20 | 0.37 |
| ▸ | PDE5A | O76074 | 4/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.33 |
| ▸ | LIMK2 | P53671 | 2/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5127403 | 0.90 | PDE5A (0.46) | PDE5A | |
| SCHEMBL5115046 | 0.88 | NPC1 (0.44) | ADORA2AADORA1USP1WDR48PDE5A | |
| SCHEMBL5120999 | 0.88 | HTT (0.42) | ADORA2AADORA1USP1WDR48PDE5A | |
| SCHEMBL5115469 | 0.87 | PDE5A (0.48) | ADORA2ACLK4ADORA1USP1WDR48 | |
| SCHEMBL5128405 | 0.86 | MAPT (0.41) | ADORA2ADYRK1ACLK4ADORA1USP1 | |
| SCHEMBL5124385 | 0.86 | ADORA2A (0.48) | ADORA2ADYRK1ACLK4ADORA1USP1 | |
| SCHEMBL5128933 | 0.86 | PDE5A (0.49) | ADORA2AADORA1PDE5AMEN1KMT2A | |
| SCHEMBL5127916 | 0.86 | PDE5A (0.52) | DYRK1ACLK4USP1WDR48PDE5A | |
| SCHEMBL5129346 | 0.85 | MEN1 (0.42) | MEN1KMT2AATMNPC1RAB9A | |
| SCHEMBL5122225 | 0.85 | PRKCI (0.42) | DYRK1ACLK4USP1WDR48PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080045529-A1 | Use Of Thienopyrimidines | MERCK PATENT GMBH (DE) | 2008-02-21 | — | — | US | disclosed |
| US-6432950-B1 | ANTICANCER AGENTS; KILLING CANCER CELLS | CELL PATHWAYS | 2002-08-13 | — | — | US | disclosed |
| US-6133271-A | Method for inhibiting neoplastic cells and related conditions by exposure thienopyrimidine derivatives | CELL PATHWAYS, INC. (US) | 2000-10-17 | — | — | US | disclosed |
| US-6110920-A | TREATMENT OF CARDIOVASCULAR DISORDERS AND IMPOTENCY | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045529-A1 | Use Of Thienopyrimidines | TIE1, DPYD, TK2 | ADORA2A 1406/4885DYRK1A 467/4885CLK4 2791/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.