Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 8/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | USP1 | O94782 | 3/20 | 0.41 |
| ▸ | WDR48 | Q8TAF3 | 3/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 5/20 | 0.36 |
| ▸ | LIMK2 | P53671 | 4/20 | 0.36 |
| ▸ | CLK1 | P49759 | 5/20 | 0.36 |
| ▸ | CLK2 | P49760 | 5/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 4/20 | 0.36 |
| ▸ | CLK3 | P49761 | 1/20 | 0.36 |
| ▸ | WNT3A | P56704 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5128521 | 0.90 | ADORA2A (0.49) | ADORA2ACLK4DYRK1AADORA1USP1 | |
| SCHEMBL5122150 | 0.89 | PRKCI (0.46) | ADORA2ACLK4DYRK1AADORA1USP1 | |
| SCHEMBL5114968 | 0.89 | KDM4E (0.45) | ADORA2AADORA1ALDH1A1 | |
| SCHEMBL5128040 | 0.89 | PDE5A (0.43) | LIMK1LIMK2 | |
| SCHEMBL5128893 | 0.88 | ADORA2A (0.53) | ADORA2ACLK4ADORA1USP2ALDH1A1 | |
| SCHEMBL5124090 | 0.88 | USP1 (0.46) | ADORA2ACLK4DYRK1AADORA1USP1 | |
| SCHEMBL5114975 | 0.87 | MAPT (0.44) | ADORA2ACLK4DYRK1AADORA1USP1 | |
| SCHEMBL5128983 | 0.87 | KMT2A (0.50) | ADORA2ACLK4DYRK1AADORA1USP1 | |
| SCHEMBL5128902 | 0.86 | ADORA2A (0.43) | ADORA2ACLK4DYRK1AADORA1USP1 | |
| SCHEMBL7508291 | 0.86 | BCDIN3D (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080045529-A1 | Use Of Thienopyrimidines | MERCK PATENT GMBH (DE) | 2008-02-21 | — | — | US | disclosed |
| US-6432950-B1 | ANTICANCER AGENTS; KILLING CANCER CELLS | CELL PATHWAYS | 2002-08-13 | — | — | US | disclosed |
| US-6133271-A | Method for inhibiting neoplastic cells and related conditions by exposure thienopyrimidine derivatives | CELL PATHWAYS, INC. (US) | 2000-10-17 | — | — | US | disclosed |
| US-6110920-A | TREATMENT OF CARDIOVASCULAR DISORDERS AND IMPOTENCY | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045529-A1 | Use Of Thienopyrimidines | TIE1, DPYD, TK2 | ADORA2A 1406/4885CLK4 2791/4885DYRK1A 467/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.