Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 9/20 | 0.52 |
| ▸ | BCDIN3D | Q7Z5W3 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5120032 | 0.87 | BCL6 (0.46) | PDE5ABCDIN3D | |
| SCHEMBL8181196 | 0.84 | PDE5A (0.52) | PDE5A | |
| SCHEMBL7020191 | 0.83 | PDE5A (0.48) | PDE5A | |
| SCHEMBL8187992 | 0.82 | PDE5A (0.47) | PDE5A | |
| SCHEMBL7017441 | 0.81 | PDE5A (0.46) | PDE5A | |
| SCHEMBL5130592 | 0.79 | BCDIN3D (0.48) | PDE5ABCDIN3D | |
| SCHEMBL5130824 | 0.79 | PDE5A (0.49) | PDE5ABCDIN3D | |
| SCHEMBL5122524 | 0.78 | BCDIN3D (0.43) | PDE5ABCDIN3D | |
| SCHEMBL5121953 | 0.78 | BCDIN3D (0.43) | PDE5ABCDIN3D | |
| SCHEMBL5123509 | 0.78 | BCDIN3D (0.43) | PDE5ABCDIN3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080045529-A1 | Use Of Thienopyrimidines | MERCK PATENT GMBH (DE) | 2008-02-21 | — | — | US | disclosed |
| EP-1685136-A1 | USE OF THIENOPYRIMIDINES | MERCK PATENT GmbH (DE) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005047292-A1 | USE OF THIENOPYRIMIDINES | MERCK PATENT GMBH (DE) | 2005-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045529-A1 | Use Of Thienopyrimidines | TIE1, DPYD, TK2 | PDE5A 2002/4885BCDIN3D 1161/4885HTR2A 2254/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.