Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 12/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8179897 | 0.94 | PDE5A (0.47) | PDE5APOLBKDM4ELMNA | |
| SCHEMBL8185179 | 0.93 | ALDH1A1 (0.49) | PDE5APOLBKDM4E | |
| SCHEMBL8184590 | 0.92 | ALDH1A1 (0.50) | PDE5AKDM4ELMNA | |
| SCHEMBL8181196 | 0.92 | PDE5A (0.52) | PDE5A | |
| SCHEMBL7017441 | 0.90 | PDE5A (0.46) | PDE5A | |
| SCHEMBL8186510 | 0.89 | ALDH1A1 (0.48) | PDE5APOLBKDM4ELMNA | |
| SCHEMBL8178637 | 0.88 | PDE5A (0.45) | PDE5APOLBKDM4ELMNA | |
| SCHEMBL8169967 | 0.88 | PDE5A (0.47) | PDE5APOLBKDM4ELMNA | |
| SCHEMBL7020191 | 0.87 | PDE5A (0.48) | PDE5A | |
| SCHEMBL8170057 | 0.87 | PDE5A (0.48) | PDE5APOLBKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130223-A | Thienopyrimidine with phosphodiesterase V inhibiting effect | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-10-10 | — | — | US | disclosed |