Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | ACP1 | P24666 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5127694 | 0.85 | HDAC1 (0.56) | RAB9AKDM4ENPC1SMN1; SMN2KDR | |
| SCHEMBL5130249 | 0.82 | HDAC1 (0.51) | RAB9AKDM4ENPC1SMN1; SMN2KDR | |
| SCHEMBL12488246 | 0.73 | HDAC1 (0.53) | RAB9AKDM4ENPC1SMN1; SMN2KDR | |
| SCHEMBL5126674 | 0.71 | HDAC1 (0.53) | RAB9AKDM4ENPC1SMN1; SMN2ACP1 | |
| SCHEMBL5123925 | 0.69 | HDAC1 (0.70) | ACP1HDAC1HDAC4HDAC3HDAC7 | |
| Hydrochloric Acid SCHEMBL5131534 | 0.68 | HDAC1 (0.62) | RAB9AKDM4ENPC1SMN1; SMN2KDR | |
| SCHEMBL5121971 | 0.67 | HDAC1 (0.69) | RAB9AKDM4ENPC1SMN1; SMN2ACP1 | |
| SCHEMBL5131328 | 0.67 | HDAC1 (0.69) | RAB9AKDM4ENPC1SMN1; SMN2ACP1 | |
| SCHEMBL29221826 | 0.67 | ACP1 (0.57) | RAB9AKDM4ENPC1SMN1; SMN2KDR | |
| SCHEMBL30858813 | 0.67 | ACP1 (0.57) | RAB9AKDM4ENPC1SMN1; SMN2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080221157-A1 | Amide Derivatives as Inhibitors of Histone Deacetylase | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGE (IT) | 2008-09-11 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221157-A1 | Amide Derivatives as Inhibitors of Histone Deacetylase | HDAC1, HDAC5, HDAC4 | RAB9A 2246/4885KDM4E 131/4885NPC1 881/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.