Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 2/20 | 0.56 |
| ▸ | IDO1 | P14902 | 8/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | KCNJ5 | P48544 | 2/20 | 0.31 |
| ▸ | KCNJ3 | P48549 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1097680 | 1.00 | CYP11B2 (0.56) | CYP11B2IDO1KCNH2TDO2ALDH1A1 | |
| SCHEMBL2821046 | 0.85 | CYP11B2 (0.62) | CYP11B2IDO1KCNH2TDO2ALDH1A1 | |
| SCHEMBL2822331 | 0.85 | CYP11B2 (0.62) | CYP11B2IDO1KCNH2TDO2ALDH1A1 | |
| SCHEMBL1097132 | 0.83 | CYP11B2 (0.61) | CYP11B2IDO1KCNH2ABCC9KMT2A | |
| SCHEMBL1097129 | 0.83 | CYP11B2 (0.61) | CYP11B2IDO1KCNH2ABCC9KMT2A | |
| SCHEMBL1096593 | 0.82 | CYP11B2 (0.64) | CYP11B2IDO1TDO2 | |
| SCHEMBL1096591 | 0.82 | CYP11B2 (0.64) | CYP11B2IDO1TDO2 | |
| SCHEMBL1097226 | 0.82 | CYP11B2 (0.50) | CYP11B2IDO1KCNH2ALDH1A1ABCC9 | |
| SCHEMBL1106699 | 0.80 | CYP11B2 (0.48) | CYP11B2IDO1KCNH2ABCC9 | |
| SCHEMBL2818690 | 0.78 | CYP11B2 (0.47) | CYP11B2IDO1KCNH2TDO2ABCC9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001866-A2 | ORGANIC COMPOUNDS | Novartis AG (CH) | 2008-12-17 | — | — | EP | disclosed |
| WO-2007117982-A2 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2007-10-18 | — | — | WO | disclosed |