Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.60 |
| ▸ | MAPT | P10636 | 8/20 | 0.60 |
| ▸ | NPC1 | O15118 | 6/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.60 |
| ▸ | RELA | Q04206 | 1/20 | 0.60 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.59 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.59 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.58 |
| ▸ | USP2 | O75604 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.57 |
| ▸ | DHODH | Q02127 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5133101 | 0.87 | CRACR2A (0.56) | RAB9AMAPTNPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5080980 | 0.78 | NPY2R (0.73) | RAB9AMAPTNPC1SMN1; SMN2NFKB1 | |
| SCHEMBL4255638 | 0.78 | DHODH (0.73) | RAB9AMAPTNPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL19799127 | 0.76 | DHODH (0.68) | RAB9AMAPTNPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5131350 | 0.75 | KDM4E (0.51) | RAB9AMAPTNPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7334315 | 0.75 | DHODH (0.68) | RAB9AMAPTNPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL7331517 | 0.75 | DHODH (0.68) | RAB9AMAPTNPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6816211 | 0.74 | MAPT (0.65) | RAB9AMAPTNPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5133040 | 0.73 | CHRM5 (0.58) | RAB9AMAPTNPC1SMN1; SMN2CHRM1 | |
| SCHEMBL28677288 | 0.73 | RXFP1 (0.57) | RAB9AMAPTNPC1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183239-B2 | Substituted piperazines and piperidines as modulators of the neuropeptide Y2 receptor | JANSSEN PHARMACEUTICA NV (BE) | 2012-05-22 | — | — | US | disclosed |
| US-20070100141-A1 | SUBSTITUTED PIPERAZINES AND PIPERIDINES AS MODULATORS OF THE NEUROPEPTIDE Y2 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070100141-A1 | SUBSTITUTED PIPERAZINES AND PIPERIDINES AS MODULATORS OF THE NEUROPEPTIDE Y2 RECEPTOR | NPY2R, NPY5R, NPY4R | RAB9A 4269/4885MAPT 4559/4885NPC1 3192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.