Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | RELA | Q04206 | 3/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | PPP1CA | P62136 | 2/20 | 0.54 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.54 |
| ▸ | MECP2 | P51608 | 1/20 | 0.54 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.54 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.54 |
| ▸ | MBD2 | Q9UBB5 | 1/20 | 0.54 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 5/20 | 0.54 |
| ▸ | CCR1 | P32246 | 2/20 | 0.54 |
| ▸ | CCR5 | P51681 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31606784 | 0.78 | CYP19A1 (0.62) | CYP19A1SMN1; SMN2MAPTNFKB1NFKB2 | |
| SCHEMBL1741719 | 0.78 | CYP19A1 (0.79) | CYP19A1SMN1; SMN2MAPTNFKB1NFKB2 | |
| SCHEMBL29516285 | 0.78 | CYP19A1 (0.62) | CYP19A1SMN1; SMN2MAPTNFKB1NFKB2 | |
| SCHEMBL14156978 | 0.78 | CYP19A1 (0.62) | CYP19A1SMN1; SMN2MAPTNFKB1NFKB2 | |
| SCHEMBL128834 | 0.78 | CYP19A1 (0.62) | CYP19A1SMN1; SMN2MAPTNFKB1NFKB2 | |
| SCHEMBL17539215 | 0.77 | CYP19A1 (0.61) | CYP19A1SMN1; SMN2MAPTNFKB1NFKB2 | |
| Bromide SCHEMBL31361535 | 0.77 | CYP19A1 (0.61) | CYP19A1SMN1; SMN2MAPTNFKB1NFKB2 | |
| SCHEMBL10272523 | 0.77 | CYP19A1 (0.61) | CYP19A1SMN1; SMN2MAPTNFKB1NFKB2 | |
| Dipyridyl SCHEMBL1571842 | 0.76 | KDM4E (0.93) | CYP19A1SMN1; SMN2MAPTNFKB1NFKB2 | |
| SCHEMBL7678939 | 0.76 | MAPT (0.81) | SMN1; SMN2MAPTNFKB1NFKB2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962863-A2 | ORALLY ACTIVE PURINE-BASED INHIBITORS OF HEAT SHOCK PROTEIN 90 | Conforma Therapeutics Corporation (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007075572-A2 | ORALLY ACTIVE PURINE-BASED INHIBITORS OF HEAT SHOCK PROTEIN 90 | CONFORMA THERAPEUTICS CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |
| US-20070129334-A1 | Orally Active Purine-Based Inhibitors of Heat Shock Protein 90 | CONFORMA THERAPEUTICS CORPORATION (US) | 2007-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129334-A1 | Orally Active Purine-Based Inhibitors of Heat Shock Protein 90 | HSP90AB1, HSP90AA1, HSP90AB2P | CYP19A1 3395/4885SMN1; SMN2 3198/4885MAPT 123/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.