Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 8/20 | 0.40 |
| ▸ | HTR2C | P28335 | 8/20 | 0.40 |
| ▸ | HTR2B | P41595 | 8/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 11/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 11/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1843690 | 1.00 | HTR2A (0.40) | HTR2AHTR2CHTR2BSLC6A2SLC6A4 | |
| SCHEMBL13688252 | 1.00 | HTR2A (0.40) | HTR2AHTR2CHTR2BSLC6A2SLC6A4 | |
| SCHEMBL13688249 | 0.83 | HTR2C (0.40) | HTR2AHTR2CHTR2BSLC6A2SLC6A4 | |
| SCHEMBL3863376 | 0.83 | HTR2C (0.40) | HTR2AHTR2CHTR2BSLC6A2SLC6A4 | |
| SCHEMBL3860709 | 0.82 | HTR1A (0.40) | HTR2AHTR2CHTR2B | |
| SCHEMBL3856531 | 0.82 | HTR1A (0.40) | HTR2AHTR2CHTR2B | |
| SCHEMBL3860706 | 0.82 | HTR1A (0.40) | HTR2AHTR2CHTR2B | |
| SCHEMBL3856535 | 0.82 | HTR1A (0.40) | HTR2AHTR2CHTR2B | |
| SCHEMBL3856526 | 0.82 | HTR1A (0.40) | HTR2AHTR2CHTR2B | |
| SCHEMBL1844188 | 0.81 | HTR2C (0.48) | HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581221-A4 | SUBSTITUTED TRICYCLIC GAMMA-CARBOLINES AS SEROTONIN RECEPTOR AGONISTS AND ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2008-11-26 | — | — | EP | disclosed |
| EP-1581221-A2 | SUBSTITUTED TRICYCLIC GAMMA-CARBOLINES AS SEROTONIN RECEPTOR AGONISTS AND ANTAGONISTS | Bristol-Myers Squibb Company (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004056324-A2 | SUBSTITUTED TRICYCLIC GAMMA-CARBOLINES AS SEROTONIN RECEPTOR AGONISTS AND ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-07-08 | — | — | WO | disclosed |