Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 12/20 | 0.51 |
| ▸ | FLT3 | P36888 | 6/20 | 0.51 |
| ▸ | FLT1 | P17948 | 6/20 | 0.51 |
| ▸ | KIT | P10721 | 6/20 | 0.51 |
| ▸ | CSF1R | P07333 | 5/20 | 0.51 |
| ▸ | FLT4 | P35916 | 5/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.51 |
| ▸ | LCK | P06239 | 4/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.51 |
| ▸ | TEK | Q02763 | 4/20 | 0.51 |
| ▸ | GSK3A | P49840 | 3/20 | 0.51 |
| ▸ | GSK3B | P49841 | 3/20 | 0.51 |
| ▸ | FRK | P42685 | 3/20 | 0.51 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.51 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.51 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.51 |
| ▸ | RET | P07949 | 3/20 | 0.51 |
| ▸ | LYN | P07948 | 3/20 | 0.51 |
| ▸ | BLK | P51451 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL58732 | 0.94 | FLT3 (0.53) | IKBKEKDRFLT3FLT1KIT | |
| SCHEMBL14686157 | 0.93 | FLT3 (0.58) | IKBKEKDRFLT3FLT1KIT | |
| SCHEMBL58646 | 0.91 | IKBKE (0.63) | IKBKEKDRFLT3FLT1KIT | |
| SCHEMBL58142 | 0.91 | ACVRL1 (0.57) | IKBKEKDRFLT3FLT1KIT | |
| SCHEMBL65684 | 0.90 | FLT3 (0.51) | IKBKEKDRFLT3FLT1KIT | |
| SCHEMBL56997 | 0.89 | FLT3 (0.51) | IKBKEKDRFLT3FLT1KIT | |
| SCHEMBL59957 | 0.89 | FLT3 (0.51) | IKBKEKDRFLT3FLT1KIT | |
| SCHEMBL14686194 | 0.89 | IKBKE (0.47) | IKBKEKDRFLT3FLT1KIT | |
| SCHEMBL58707 | 0.88 | IKBKE (0.49) | IKBKEKDRFLT3FLT1KIT | |
| SCHEMBL57821 | 0.88 | IKBKE (0.60) | IKBKEKDRFLT3FLT1KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957485-B1 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | BAYER HEALTHCARE LLC (US) | 2013-02-13 | — | — | EP | claimed |
| EP-1957485-A2 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | Bayer Healthcare, LLC (US) | 2008-08-20 | — | — | EP | claimed |
| WO-2007064931-A2 | SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | BAYER HEALTHCARE LLC (US) | 2007-06-07 | — | — | WO | claimed |