Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.50 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.50 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.50 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.50 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.50 |
| ▸ | DRD3 | P35462 | 2/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.50 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.50 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.50 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.50 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.50 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.50 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11889628 | 0.82 | KCNH2 (0.50) | OPRM1KCNH2GRIN2DGRIN1GRIN2A | |
| SCHEMBL22312262 | 0.81 | GRIN1 (0.76) | OPRM1KCNH2GRIN2DGRIN1GRIN2A | |
| SCHEMBL13740317 | 0.76 | CHRM3 (0.58) | OPRM1KCNH2GRIN2DGRIN1GRIN2A | |
| SCHEMBL8939167 | 0.75 | KCNN4 (0.47) | OPRM1KCNH2GRIN2DGRIN1GRIN2A | |
| SCHEMBL10828978 | 0.74 | KMT2A (0.52) | OPRM1KCNH2GRIN2DGRIN1GRIN2A | |
| SCHEMBL25341236 | 0.70 | CHRM3 (0.63) | OPRM1KCNH2GRIN2DGRIN1GRIN2A | |
| Hydrochloric Acid SCHEMBL30307081 | 0.69 | CHRM3 (0.61) | OPRM1KCNH2GRIN2DGRIN1GRIN2A | |
| SCHEMBL22313255 | 0.69 | GRIN1 (0.74) | OPRM1KCNH2GRIN2DGRIN1GRIN2A | |
| SCHEMBL3652874 | 0.68 | CYP2D6 (0.48) | OPRM1KCNH2GRIN2DGRIN1GRIN2A | |
| SCHEMBL27761197 | 0.68 | OPRM1 (0.61) | OPRM1KCNH2GRIN2DGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11224576-B2 | Process for the production of an abuse-proofed dosage form | Grünenthal GmbH (DE) | 2022-01-18 | — | — | US | disclosed |
| US-20200170954-A1 | PHARMACEUTICAL DOSAGE FORMS COMPRISING POLY(EPSILON-CAPROLACTONE) AND POLYETHYLENE OXIDE | PURDUE PHARMA LP (US) | 2020-06-04 | — | — | US | disclosed |
| US-10653776-B2 | Compositions and methods for reducing overdose | INTELLIPHARMACEUTICS CORP. (CA) | 2020-05-19 | — | — | US | disclosed |
| US-20190321358-A1 | ABUSE-PROOFED DOSAGE FORM | Grünenthal GmbH (DE) | 2019-10-24 | — | — | US | disclosed |
| US-20190275153-A1 | COMPOSITIONS AND METHODS FOR REDUCING OVERDOSE | INTELLIPHARMACEUTICS CORP. (CA) | 2019-09-12 | — | — | US | disclosed |
| US-10293046-B2 | Compositions and methods for reducing overdose | INTELLIPHARMACEUTICS CORP. (CA) | 2019-05-21 | — | — | US | disclosed |
| US-20180243237-A1 | ABUSE-PROOFED DOSAGE FORM | Grünenthal GmbH (DE) | 2018-08-30 | — | — | US | disclosed |
| WO-2018137018-A1 | IMPROVED COMPOSITIONS AND METHODS FOR REDUCING OVERDOSE | ODIDI ISA (CA) | 2018-08-02 | — | — | WO | disclosed |
| US-9801939-B2 | Compositions and methods for reducing overdose | ISA ODIDI (CA) | 2017-10-31 | — | — | US | disclosed |
| US-20170258912-A1 | COMPOSITIONS AND METHODS FOR REDUCING OVERDOSE | 1001112561 ONTARIO INC. (CA) | 2017-09-14 | — | — | US | disclosed |
| WO-2014059512-A1 | ORAL DRUG DELIVERY FORMULATIONS | ODIDI ISA (CA) | 2014-04-24 | — | — | WO | disclosed |
| US-20140086847-A1 | DOSAGE FORM THAT IS SAFEGUARDED FROM ABUSE | GRUNENTHAL GMBH (DE) | 2014-03-27 | — | — | US | disclosed |
| US-20140080915-A1 | Abuse-proofed dosage forms | GRUENENTHAL GMBH (DE) | 2014-03-20 | — | — | US | disclosed |
| WO-2013084059-A1 | PHARMACEUTICAL DOSAGE FORMS COMPRISING POLY (EPSILON- CAPROLACTONE) AND POLYETHYLENE OXIDE | PURDUE PHARMA L.P. (US) | 2013-06-13 | — | — | WO | disclosed |
| US-8420056-B2 | Abuse-proofed dosage form | GRUNENTHAL GMBH (DE) | 2013-04-16 | — | — | US | disclosed |
| US-20080247959-A1 | FORM OF ADMINISTRATION SECURED AGAINST MISUSE | GRUNENTHAL GMBH (DE) | 2008-10-09 | — | — | US | disclosed |
| US-20070183979-A1 | Abuse-proofed dosage form | ENDO PHARMACEUTICALS, INC. | 2007-08-09 | — | — | US | disclosed |
| US-20070183980-A1 | Thermoforming by extrusion without discoloration; controlled release | ENDO PHARMACEUTICALS, INC. | 2007-08-09 | — | — | US | disclosed |
| US-20060193782-A1 | Abuse-proofed dosage form | ENDO PHARMACEUTICALS, INC. | 2006-08-31 | — | — | US | disclosed |
| US-20050031546-A1 | Abuse-proffed dosage form | ENDO PHARMACEUTICALS, INC. | 2005-02-10 | — | — | US | disclosed |