SCHEMBL5132872

SCHEMBL5132872

CCC(CC)C(=O)Nc1ccc(N2CCN(C(Cc3ccccc3)C(=O)N(CC)CC)CC2)c(C#N)c1F

nearest known ligand 0.53

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
NPY2R P49146 20/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5077949 0.87 NPY2R (0.70) NPY2R
SCHEMBL5132874 0.82 NPY2R (0.53) NPY2R
SCHEMBL5132876 0.79 NPY2R (0.45) NPY2R
SCHEMBL5077991 0.76 NPY2R (0.73) NPY2R
SCHEMBL7607333 0.74 NPY2R (0.68) NPY2R
SCHEMBL5132871 0.73 NPY2R (0.43) NPY2R
SCHEMBL7599325 0.72 NPY2R (0.67) NPY2R
SCHEMBL5132897 0.72 NPY2R (0.73) NPY2R
SCHEMBL5128106 0.71 NPY2R (0.77) NPY2R
SCHEMBL5084478 0.70 NPY2R (0.80) NPY2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8183239-B2 Substituted piperazines and piperidines as modulators of the neuropeptide Y2 receptor JANSSEN PHARMACEUTICA NV (BE) 2012-05-22 US claimed