Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | MMP14 | P50281 | 1/20 | 0.45 |
| ▸ | CRHBP | P24387 | 3/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3033674 | 0.93 | MAPT (0.64) | MAPTMMP14CRHBPCRHR2POLB | |
| SCHEMBL27512370 | 0.84 | TAAR1 (0.39) | MAPTMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL18660127 | 0.79 | MAPT (0.77) | MAPTMMP14CRHBPCRHR2POLB | |
| SCHEMBL12006709 | 0.79 | POLB (0.52) | MAPTCRHBPCRHR2POLBMEN1 | |
| SCHEMBL20067707 | 0.76 | MAPT (0.51) | MAPTCRHBPCRHR2POLBMEN1 | |
| SCHEMBL18562081 | 0.76 | BRAF (0.41) | MAPTMEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL18967271 | 0.76 | MAOB (0.62) | MAPT | |
| SCHEMBL25355301 | 0.75 | MAPT (0.50) | MAPTCRHBPCRHR2POLBMEN1 | |
| SCHEMBL1728626 | 0.75 | MAPT (0.70) | MAPTMMP14CRHBPCRHR2POLB | |
| SCHEMBL16706324 | 0.75 | MAPT (0.81) | MAPTMMP14CRHBPCRHR2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008020203-A1 | PYRIDINYLQUINAZ0LINAMINE DERIVATIVES AND THEIR USE AS B-RAF INHIBITORS | ASTRAZENECA AB (SE) | 2008-02-21 | — | — | WO | disclosed |