Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 12/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.56 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.56 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.56 |
| ▸ | DHODH | Q02127 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1689215 | 0.87 | HDAC2 (0.75) | HDAC1HDAC2HDAC3 | |
| SCHEMBL1689174 | 0.79 | HDAC1 (0.67) | HDAC1HDAC2HDAC3 | |
| SCHEMBL5035388 | 0.77 | HDAC1 (0.61) | HDAC1HDAC2 | |
| SCHEMBL1689312 | 0.77 | HDAC2 (0.62) | HDAC1HDAC2HDAC3 | |
| SCHEMBL2108411 | 0.76 | HDAC1 (0.74) | HDAC1HDAC2HDAC3 | |
| SCHEMBL18653509 | 0.74 | HDAC2 (0.75) | HDAC1HDAC2HDAC3 | |
| SCHEMBL1689389 | 0.74 | HDAC1 (0.67) | HDAC1HDAC2HDAC3 | |
| SCHEMBL2108793 | 0.74 | HDAC2 (0.65) | HDAC1HDAC2HDAC3 | |
| SCHEMBL16380794 | 0.72 | HDAC2 (1.00) | HDAC1HDAC2HDAC3 | |
| SCHEMBL21446872 | 0.72 | PDCD1 (1.00) | HDAC1HDAC2HDAC3PDCD1CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896395-A2 | MODIFIED MALONATE DERIVATIVES | Merck & Co., Inc. (US) | 2008-03-12 | — | — | EP | disclosed |
| WO-2007002248-A2 | MODIFIED MALONATE DERIVATIVES | MERCK & CO., INC. (US) | 2007-01-04 | — | — | WO | disclosed |