Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | SFRP1 | Q8N474 | 2/20 | 0.39 |
| ▸ | RBP4 | P02753 | 2/20 | 0.39 |
| ▸ | LIPE | Q05469 | 2/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1840393 | 1.00 | USP30 (0.41) | USP30RORCTACR1P2RX7GPR119 | |
| SCHEMBL1842912 | 1.00 | USP30 (0.41) | USP30RORCTACR1P2RX7GPR119 | |
| SCHEMBL1842914 | 1.00 | USP30 (0.41) | USP30RORCTACR1P2RX7GPR119 | |
| SCHEMBL6494299 | 0.84 | GPR119 (0.43) | USP30RORCGPR119JAK2JAK1 | |
| SCHEMBL6494303 | 0.84 | GPR119 (0.43) | USP30RORCGPR119JAK2JAK1 | |
| SCHEMBL1841886 | 0.84 | IDO1 (0.40) | USP30RORCTACR1GPR119JAK2 | |
| SCHEMBL1843090 | 0.84 | IDO1 (0.40) | USP30RORCTACR1GPR119JAK2 | |
| SCHEMBL1843088 | 0.84 | IDO1 (0.40) | USP30RORCTACR1GPR119JAK2 | |
| SCHEMBL1843411 | 0.83 | GPR119 (0.42) | USP30GPR119JAK2JAK1TYK2 | |
| SCHEMBL1844576 | 0.82 | GPR119 (0.44) | USP30GPR119JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581221-A4 | SUBSTITUTED TRICYCLIC GAMMA-CARBOLINES AS SEROTONIN RECEPTOR AGONISTS AND ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2008-11-26 | — | — | EP | disclosed |
| EP-1581221-A2 | SUBSTITUTED TRICYCLIC GAMMA-CARBOLINES AS SEROTONIN RECEPTOR AGONISTS AND ANTAGONISTS | Bristol-Myers Squibb Company (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004056324-A2 | SUBSTITUTED TRICYCLIC GAMMA-CARBOLINES AS SEROTONIN RECEPTOR AGONISTS AND ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-07-08 | — | — | WO | disclosed |