Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 5/20 | 0.54 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | BLM | P54132 | 2/20 | 0.44 |
| ▸ | LDHA | P00338 | 1/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.43 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 4/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | HBB | P68871 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL11732387 | 1.00 | CA4 (0.54) | CA4FAHD1MEN1KMT2ABLM | |
| Bicarbonate SCHEMBL11215584 | 0.96 | MEN1 (0.50) | CA4FAHD1MEN1KMT2ABLM | |
| Bicarbonate SCHEMBL28102608 | 0.92 | MEN1 (0.46) | CA4FAHD1MEN1KMT2ABLM | |
| Bicarbonate SCHEMBL28850573 | 0.92 | MEN1 (0.46) | CA4FAHD1MEN1KMT2ABLM | |
| Bicarbonate SCHEMBL27977608 | 0.92 | MEN1 (0.46) | CA4FAHD1MEN1KMT2ABLM | |
| Bicarbonate SCHEMBL11218040 | 0.92 | MEN1 (0.46) | CA4FAHD1MEN1KMT2ABLM | |
| Bicarbonate SCHEMBL11755316 | 0.92 | MEN1 (0.46) | CA4FAHD1MEN1KMT2ABLM | |
| Bicarbonate SCHEMBL11218041 | 0.92 | MEN1 (0.46) | CA4FAHD1MEN1KMT2ABLM | |
| Bicarbonate SCHEMBL28309302 | 0.92 | MEN1 (0.46) | CA4FAHD1MEN1KMT2ABLM | |
| Bicarbonate SCHEMBL28243262 | 0.92 | MEN1 (0.46) | CA4FAHD1MEN1KMT2ABLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080056928-A1 | Functionalisation of Particles | DOW CORNING CORPORATION | 2008-03-06 | — | — | US | claimed |