Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2928262 | 0.83 | HPGD (0.43) | HPGDNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL2927679 | 0.78 | NPC1 (0.47) | HPGDNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL2932783 | 0.75 | HPGD (0.54) | HPGDNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL7260307 | 0.74 | NPC1 (0.56) | HPGDNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL2924638 | 0.72 | NPC1 (0.49) | HPGDNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL5133488 | 0.71 | MAPT (0.46) | HPGDSMN1; SMN2LMNAKDM4ECYP3A4 | |
| SCHEMBL2932300 | 0.71 | HPGD (0.45) | HPGDNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL2927267 | 0.71 | NPC1 (0.61) | HPGDNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL2934550 | 0.71 | HPGD (0.46) | HPGDNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL2924973 | 0.70 | MAP4K4 (0.60) | HPGDNPC1RAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1987028-A2 | BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS AURORA KINASE INHIBITORS | Transtech Pharma, Inc. (US) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007095124-A2 | BENZAZOLE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE AS AURORA KINASE INHIBITORS | TRANSTECH PHARMA, INC. (US) | 2007-08-23 | — | — | WO | disclosed |