Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 12/20 | 1.00 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.65 |
| ▸ | GPR183 | P32249 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3366897 | 0.89 | HDAC1 (0.80) | HDAC1HDAC6HDAC8HDAC2 | |
| SCHEMBL3366899 | 0.89 | HDAC1 (0.80) | HDAC1HDAC6HDAC8HDAC2 | |
| SCHEMBL4574406 | 0.82 | HDAC1 (0.70) | HDAC1HDAC6GPR183ESR1 | |
| SCHEMBL4572978 | 0.82 | HDAC1 (0.70) | HDAC1HDAC6GPR183ESR1 | |
| SCHEMBL18469368 | 0.78 | HDAC1 (0.63) | HDAC1 | |
| SCHEMBL15552440 | 0.78 | HDAC1 (0.63) | HDAC1 | |
| SCHEMBL10817405 | 0.75 | IP6K1 (0.63) | HDAC1HDAC6ESR1 | |
| SCHEMBL30050466 | 0.75 | IP6K1 (0.63) | HDAC1HDAC6ESR1 | |
| SCHEMBL14972936 | 0.75 | IP6K1 (0.63) | HDAC1HDAC6ESR1 | |
| SCHEMBL16215254 | 0.75 | HDAC1 (0.58) | HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673349-A4 | BENZIMIDAZOLE DERIVATES: PREPARATION AND PHARMACEUTICAL APPLICATIONS | S BIO PTE LTD (SG) | 2008-01-23 | — | — | EP | disclosed |
| EP-1673349-A1 | BENZIMIDAZOLE DERIVATES: PREPARATION AND PHARMACEUTICAL APPLICATIONS | S*Bio Pte Ltd (SG) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005028447-A1 | BENZIMIDAZOLE DERIVATES: PREPARATION AND PHARMACEUTICAL APPLICATIONS | S*BIO PTE LTD (SG) | 2005-03-31 | — | — | WO | disclosed |