Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL708718 | 0.83 | PDE4B (0.42) | ALDH1A1 | |
| SCHEMBL1525543 | 0.83 | — | — | |
| SCHEMBL5133822 | 0.82 | TP53 (0.33) | ALDH1A1SLC6A2SLC6A4SLC6A3GAA | |
| SCHEMBL5133200 | 0.78 | SLC6A2 (0.34) | ALDH1A1SLC6A2SLC6A4SLC6A3GAA | |
| SCHEMBL14968794 | 0.77 | SMN1; SMN2 (0.41) | ALDH1A1SLC6A2SLC6A4SLC6A3GAA | |
| SCHEMBL2800045 | 0.75 | MCHR1 (0.46) | — | |
| SCHEMBL14636183 | 0.74 | SLC6A2 (0.39) | ALDH1A1SLC6A2SLC6A4SLC6A3GAA | |
| SCHEMBL22098387 | 0.72 | HTT (0.37) | SMN1; SMN2 | |
| SCHEMBL22983193 | 0.71 | ITGB3 (0.39) | — | |
| SCHEMBL26619704 | 0.71 | ITGB3 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893599-A1 | COMPOUNDS FOR THE TREATMENT OF MULTI-DRUG RESISTANT BACTERIAL INFECTIONS | AstraZeneca AB (SE) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006134378-A1 | COMPOUNDS FOR THE TREATMENT OF MULTI-DRUG RESISTANT BACTERIAL INFECTIONS | ASTRAZENECA AB (SE) | 2006-12-21 | — | — | WO | disclosed |