Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 8/20 | 0.61 |
| ▸ | CHRNA3 | P32297 | 8/20 | 0.61 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.51 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.51 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.51 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.51 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4375014 | 1.00 | CHRNB4 (0.61) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNB1 | |
| SCHEMBL4375016 | 1.00 | CHRNB4 (0.61) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNB1 | |
| SCHEMBL4966709 | 0.91 | CHRNB4 (0.64) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNB1 | |
| SCHEMBL4966717 | 0.91 | CHRNB4 (0.64) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNB1 | |
| SCHEMBL1655800 | 0.83 | ACHE (0.48) | CHRNB4CHRNA3 | |
| SCHEMBL4977559 | 0.83 | ALOX5AP (0.43) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL4370059 | 0.83 | ALOX5AP (0.43) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL4374846 | 0.83 | ALOX5AP (0.43) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL4368887 | 0.82 | CHRNB4 (0.49) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNB1 | |
| SCHEMBL5420654 | 0.82 | CHRNB4 (0.49) | CHRNB4CHRNA3CHRNB2CHRNA4CHRNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1971604-A2 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER DISEASES | Amgen Inc. (US) | 2008-09-24 | — | — | EP | disclosed |
| WO-2007048070-A2 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER DISEASES | AMGEN INC. (US) | 2007-04-26 | — | — | WO | disclosed |