Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 16/20 | 0.57 |
| ▸ | HTR2B | P41595 | 16/20 | 0.57 |
| ▸ | HTR2C | P28335 | 15/20 | 0.57 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5137540 | 0.96 | HTR2A (0.53) | HTR2AHTR2BHTR2CADRB1HTR1A | |
| SCHEMBL5136215 | 0.92 | HTR2A (0.57) | HTR2AHTR2BHTR2CADRB1HTR1A | |
| SCHEMBL5135288 | 0.91 | HTR2A (0.51) | HTR2AHTR2BHTR2CTP53SMN1; SMN2 | |
| SCHEMBL5136312 | 0.91 | HTR2A (0.44) | HTR2AHTR2BHTR2CTP53SMN1; SMN2 | |
| SCHEMBL5137390 | 0.88 | C5AR1 (0.44) | HTR2AHTR2BHTR2CTP53 | |
| SCHEMBL4768999 | 0.88 | C5AR1 (0.51) | HTR2AHTR2BHTR2CSMN1; SMN2 | |
| SCHEMBL5136966 | 0.88 | HTR2A (0.43) | HTR2AHTR2BHTR2CTP53SMN1; SMN2 | |
| SCHEMBL5136963 | 0.87 | C5AR1 (0.47) | HTR2AHTR2BHTR2CSMN1; SMN2 | |
| SCHEMBL5136272 | 0.87 | C5AR1 (0.43) | HTR2AHTR2BHTR2CTP53SMN1; SMN2 | |
| SCHEMBL5135235 | 0.86 | C5AR1 (0.54) | HTR2AHTR2BHTR2CADRB1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490044-A4 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORP (US) | 2008-04-16 | — | — | EP | disclosed |
| EP-1490044-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003084524-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2003-10-16 | — | — | WO | disclosed |