Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4856339 | 0.81 | ALDH1A1 (0.31) | — | |
| SCHEMBL4520219 | 0.77 | BACE1 (0.45) | BACE1 | |
| Hydrochloric Acid SCHEMBL4785825 | 0.73 | BACE1 (0.36) | BACE1 | |
| SCHEMBL4928167 | 0.68 | BACE1 (0.39) | BACE1 | |
| SCHEMBL4783919 | 0.67 | BACE1 (0.63) | BACE1 | |
| SCHEMBL8197070 | 0.66 | BACE1 (0.61) | BACE1 | |
| SCHEMBL4532322 | 0.66 | APP (0.46) | BACE1 | |
| SCHEMBL8199166 | 0.66 | BACE1 (0.60) | BACE1 | |
| Hydrochloric Acid SCHEMBL4919314 | 0.66 | BACE1 (0.60) | BACE1 | |
| Hydrochloric Acid SCHEMBL4786407 | 0.65 | BACE1 (0.59) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979324-A2 | NOVEL 2-AMINO-IMIDAZOLE-4-ONE COMPOUNDS AND THEIR USE IN THE MANUFACTURE OF A MEDICAMENT TO BE USED IN THE TREATMENT OF COGNITIVE IMPAIRMENT, ALZHEIMER'S DISEASE, NEURODEGENERATION AND DEMENTIA | Astra Zeneca AB (SE) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007058602-A2 | NOVEL 2-AMINO-IMIDAZOLE-4-ONE COMPOUNDS AND THEIR USE IN THE MANUFACTURE OF A MEDICAMENT TO BE USED IN THE TREATMENT OF COGNITIVE IMPAIRMENT, ALZHEIMER’S DISEASE, NEURODEGENERATION AND DEMENTIA. | ASTRAZENECA AB (SE) | 2007-05-24 | — | — | WO | disclosed |