Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.39 |
| ▸ | USP5 | P45974 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 2/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.35 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15869588 | 1.00 | P2RX7 (0.41) | P2RX7KDM4ENR4A1NR4A2NR4A3 | |
| SCHEMBL12668525 | 0.83 | P2RX7 (0.45) | P2RX7KDM4EUSP5TSHRLMNA | |
| SCHEMBL1589819 | 0.83 | PARP1 (0.48) | P2RX7KDM4EUSP5TSHRALDH1A1 | |
| SCHEMBL1590034 | 0.83 | PARP1 (0.48) | P2RX7KDM4EUSP5TSHRALDH1A1 | |
| SCHEMBL12668523 | 0.83 | P2RX7 (0.45) | P2RX7KDM4EUSP5TSHRLMNA | |
| SCHEMBL1589818 | 0.83 | PARP1 (0.48) | P2RX7KDM4EUSP5TSHRALDH1A1 | |
| SCHEMBL1897096 | 0.82 | P2RX7 (0.42) | P2RX7KDM4EUSP5TSHRLMNA | |
| SCHEMBL1899104 | 0.82 | P2RX7 (0.42) | P2RX7KDM4EUSP5TSHRLMNA | |
| SCHEMBL1897092 | 0.82 | P2RX7 (0.42) | P2RX7KDM4EUSP5TSHRLMNA | |
| SCHEMBL12725533 | 0.80 | P2RX7 (0.41) | P2RX7KDM4EUSP5TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937643-B1 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | SECOND GENOME INC (US) | 2016-07-13 | — | — | EP | disclosed |
| US-8779144-B2 | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof | EVOTEC (US) INC. (US) | 2014-07-15 | — | — | US | disclosed |
| EP-1937643-A2 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | Renovis, Inc. (US) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007109160-A9 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | RENOVIS INC (US) | 2007-11-15 | — | — | WO | disclosed |
| WO-2007109160-A2 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2007-09-27 | — | — | WO | disclosed |